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Biotransformation enzymes

Bhuvaneswari, V., Velmurugan, B., and Nagini, S. 2002. Induction of glutathione-dependent hepatic biotransformation enzymes by lycopene in the hamster cheek pouch carcinogenesis model. J Biochem Mol Biol Biophys 6 257-260. [Pg.479]

Romeo, M., A. Mathieu, M. Gnassia-Barelli, A. Romana, and M. Lafaurie. 1994. Heavy metal content and biotransformation enzymes in two fish species from the NW Mediterranean. Afar Ecol. Pmg. Ser. 107 15-22. [Pg.229]

Lemaire, P., A. Mathieu, J. Giudicelli, and M. Lafaurie. 1992c. Effect of diet on the responses of hepatic biotransformation enzymes to benzo[a]pyrene in the European sea bass (Dicentrarchus labrax). Comp. Biochem. Physiol. 102C 413-420. [Pg.1402]

Lemaire-Gony, S. and P. Lemaire. 1992. Interactive effects of cadmium and benzo[a]pyrene on cellular structure and biotransformation enzymes of the liver of the European eel Anguilla anguilla. Aquat. Toxicol. 22 145-160. [Pg.1402]

Croci, T. and Williams, G.M. (1985). Activities of several phase I and phase II xenobiotic biotransformation enzymes in cultured hepatocytes from male and female rats. Biochem. Pharm. 17(34) 3029-3035. [Pg.678]

Vrolijk NH, Targett NM (1992) Biotransformation enzymes in Cyphoma gibbosum (Gastropoda, Ovulidae) - implications for detoxification of gorgonian allelochemicals. Mar Ecol Prog Ser... [Pg.228]

Lung metabolism studies would greatly benefit from the availability of reliable in vitro experimental models that are able to reproduce biochemical and toxicological processes that occur in the human lung. Because of differences in the expression profiles of biotransformation enzymes between animal species, conclusions drawn from experimental animals may not be representative of what occurs in the human lung. [Pg.246]

Calu-3 cells have shown the ability to perform fatty acid esterification of budes-onide [132], In pre-clinical studies, this esterification results in a prolonged local tissue binding and efficacy, which is not found when the esterification is inhibited [133]. The precise mechanism remains undefined in that the identity of specific enzyme(s) responsible for this metabolic reaction is unclear [134], Assessment of the potential toxicity and metabolism of pharmaceuticals and other xenobiotics using in vitro respiratory models is still at its infancy. The development of robust in vitro human models (i.e., cell lines from human pulmonary origin) has the potential to contribute significantly to better understanding the role of biotransformation enzymes in the bioactivation/detoxication processes in the lung. [Pg.249]

Thomas DA, Lacy SA, Everitt Jl, et al. 1989b. Effects of methyl bromide (MeBr) on nasal-tissue biotransformation enzymes [Abstract]. In Feron VJ, Bosland MC, eds. Nasal carcinogenesis in rodents Relevance to human risk. Wageningen, The Netherlands Pudoc, 226. [Pg.107]

Krul C, Hageman G (1998) Analysis of urinary caffeine metabolites to assess biotransformation enzyme activities by reversed-phase high-performance liquid chromatography, J ChromatogrB Biomed Sci Appl 709(l) 27-34... [Pg.57]

In order to use PBTK modeling in the assessment of mixtures, Cassee et al. (1998) suggest that one of the components is first modeled and regarded as the prime toxicant being modified by the other components. Based on in vitro data on the other components, effects of, e.g., inhibition or induction of specific biotransformation isoenzymes can be incorporated in the model. Effects of competition between chemicals in a mixture for the same biotransformation enzymes may also be incorporated by translating the effects into effects on the Michaelis-Menten parameters that are then incorporated into the model. [Pg.377]

Similar or identical biotransformation pathways, including ability to induce or inhibit biotransformation enzymes... [Pg.396]

Parkki MG, Marniemi J, Vainio H Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo. Toxicol Appl Pharmacol 38 59-70, 1976... [Pg.643]

NT099 Nair, U. ]., N. Ammigan, J. J. Kayal, and S. V. Bhide. Species differences in hepatic pulmonary and upper gastrointestinal tract biotransformation enzymes on long-term feeding of masheri—a pyrolyzed tobacco product. [Pg.345]

Dorough. Effects of cigarette smoke and dietary vitamin E levels on selected lung and hepatic biotransformation enzymes in mice. Drug Nutr Interact 1985 3(4) 213-222. [Pg.348]

Cytochrome P450 1A content CYPIA Phase I biotransformation enzyme PAHs, PCBs, PCDDs, PCDFs Liver tissue 6-15... [Pg.13]

The biotransformation enzyme GST showed significant and unambiguous decreased responses compared to references but it did not correlate with contamination levels for PCBs and PAHs. Since it appeared to be influenced by salinity differences it would seem to have little value as an estuarine biomarker. [Pg.29]

Dalvi RR. Alteration in hepatic phase I and phase II biotransformation enzymes by garlic oil in rats. Toxicol Lett 1992 60 299-305. [Pg.45]


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Biotransformation enzyme adaptation

Biotransformation enzyme induction

Biotransformation enzyme inhibition

Biotransformation enzyme kinetics

Biotransformation enzymes, variants

Biotransformation pathways oxidative enzymes

Biotransformations enzymes)

Biotransformations multi-enzyme systems

Commercial enzymes industrial biotransformations

Drug biotransformation enzyme systems, cytochromes P450

Enzymes in biotransformation

Enzymes industrial biotransformations

Industrial biotransformations isolated enzymes

Industrial biotransformations microbial enzymes

Interrelationships between enzymes and cells choosing the best biotransformation system

Multi-Step Enzyme Catalysis: Biotransformations and Chemoenzymatic Synthesis

Oxidizing Enzymes in Multi-Step Biotransformation Processes

Rates of Biotransformations Enzymes

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