Biotechnologies custom synthesis

Piletsky, S. Piletska, E.V. Karim, K. Foster, G. Legge, C. Turner, A. P. F., Custom synthesis of molecular imprinted polymers for biotechnological application Preparation of a polymer selective for tylosin, Anal. Chim. Acta. 2004, 504, 123-130... 

This biotechnology company has been a partner to researchers engaged in the field of DNA/RNA synthesis by starting as a supplier of high purity products and evolving to an active contract researcher. ChemGenes Corporation has developed its expertise in the field of DNA/RNA synthesis. Both, the reagent products and the specialized custom services are provided, either as services or as a research contractor. 

Hydrolases were in the first catalogue after the company was founded in 1950 but, not surprisingly, the chiral molecules originated mainly from the chiral pool. The first biocatalytic reactions were developed with kidney acylases and later with esterases and lipases, in the beginning mainly animal-derived biocatalysts [10], The set-up of in-house biocatalyst production from microbial and plant sources as well as the construction of a new biotechnology laboratory with ten fermenters of up to 300 L total volume, allow the development and production of improved biocatalysts and for them to be applied in the asymmetric synthesis of laboratory chemicals. There are today more than 100 biocatalytic processes in routine production and a project management team is handling custom biotransformations. 

Industrial commodity polymers are the backbone of the world chemical industry and provide extreme value and stability that are appropriate for a plethora of applications. Their ease of synthesis enables the utilization of a large number of chemical functionalities that influence their final properties, but with relatively little control over 3D polymer shape on the molecular scale. By contrast, biological polymers, primarily proteins, feature a relatively small pool of chemical functionalities, yet their molecular stmctures can be almost infinitely custom-tailored for specific applications. However, biomacromolecules are orders of magnitude more expensive to produce and generally display much poorer stability in harsh conditions, and thus are limited, essentially, to medical and biotechnology applications. ... 

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