Bioresorbable polymers polymer characterization

First, a brief overview of the degradation mechanism and the main factors that influence hydrolysis of bioresorbable polymers is provided. Then, the modeling approaches that can be used for characterizing the behavior of biodegradable devices will be summarized. 

To satisfy the requirements of biocompalibility and biodegradability, the materials used in medical and pharmaceutical fields for intravenous injection are generally characterized by polymeric NPs based on polyesters, which are biocompatible and biodegradable. In this chapter, we cover the most common bioresorbable polymer materials that are synthesized. Then, we discuss the methods adopted for the synthesis of NPs made of bioresorbable polymers. Finally, we present the most common applications of bioresorbable polymer NPs in medical and pharmaceutical fields and the hurdles involved in their use. 

To prepare nanocomposite scaffolds based on bioresorbable polymers (PLDL), two different methods were used salt leaching and a combination of salt leaching and gas foaming techniques. The obtained scaffolds were characterized by good mechanical properties and high porosity, required for materials for bone tissue regeneration. Additionally, high water absorption for these scaffolds, especially for nanocomposite scaffolds, may indicate the presence of interconnected... 

Kharas, G. B., Kamenetsky, M., Simantirakis, J., Beinlich, K., C, Rizzo, A.-M., T., Caywood, G., A. Watson, K. 1997. Synthesis and characterization of fumarate-based polyesters for use in bioresorbable bone cement composites. Journal of Applied Polymer Science, 66, 15. 

Shalaby, S.W., 1994. Biomedical Polymers Designed-to-Degrade Systems, Hanser Publishers, New York. Shieh, S.J., Zimmerman, M.C., and Parsons, J.R., 1990. Preliminary characterization of bioresorbable and nonresorbable synthetic fibers for the repair of soft tissue injuries. /. Biomed. Mater. Res., 24 789-808. 

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