Biomaterials drug delivery

Keywords Biomaterial Drug delivery Hydrogel Peptide Polypeptide Self-assembly Tissue engineering... 

Langer, R., Peppas, N.A. (2003). Advances in biomaterials, drug delivery, and bionanotechnology. AIChE Journal, 49, 2990-3006. 

Chitosan finds wide applications in biomaterials, drug-delivery systems [39,40], food additives, water clarification [41], and as support for cells, enzymes [42], and catalysts [4, 5]. 

J. Stopek, B. Cuevas, J. Hotter, B. Nentwick, A. Irfan, and S. Tsai, Biomaterial drug delivery and surface modification compositions, US Patent 7 850 982, assigned to Tyco Healthcare Group LP (North Haven, CT), December 14, 2010. 

The surface active behavior of proteins is frequently employed in medicine and industry, for example, in the development of new biomaterials, drug delivery, and... 

Approach 3 Insights into multipurpose chitosan/protein-based gels as functional biomaterial drug-delivery prototypes. 

V. Perchyonok, S. Zhang, N.J. Basson, T. Oberholzer, Insights into chitosan-nystatin and chitosan-naproxen based gels as functional biomaterial drug delivery prototypes In vitro approach, unpubhshed data. 

Ranade, S.V., Richard, R.E., and Hehnus, M.N. Styrenic block copolymers for biomaterial and drug delivery applications, Acta Biomater., 1, 137, 2005. 

Fu J, Fiegel J, Krauland E, and Hanes J. New polymeric carriers for controlled drug delivery following inhalation or injection [J]. Biomaterials, 2002, 23, 4425 1433. 

Phosphazene polymers can act as biomaterials in several different ways [401, 402,407]. What is important in the consideration of skeletal properties is that the -P=N- backbone can be considered as an extremely stable substrate when fluorinated alcohols [399,457] or phenoxy [172] substituents are used in the substitution process of the chlorine atoms of (NPCl2)n> but it becomes highly hydrolytically unstable when simple amino acid [464] or imidazole [405-407] derivatives are attached to the phosphorus. In this case, an extraordinary demolition reaction of the polymer chain takes place under mild hydrolytic conditions transforming skeletal nitrogen and phosphorus into ammonium salts and phosphates, respectively [405-407,464]. This opens wide perspectives in biomedical sciences for the utilization of these materials, for instance, as drug delivery systems [213,401,405,406,464] and bioerodible substrates [403,404]. 

Polyphosphazenes can be considered as biomaterials in several different ways, depending on the type of utilization one can predict for these substrates. In this regard, we will consider three different topics concerning water-soluble POPs and their hydrogels, bioerodible POPs for drug delivery systems and for tissue engineering, and the surface implications of POP films. 

Shih, C., Higuchi, T., and Himmelstein, K. J., Drug delivery from catalyzed erodible polymeric matrices of poly(ortho esters). Biomaterials. 5, 237-240, 1984. 

Upadhyay KK, Bhatt AN, Mishra AK, Dwarakanath BS, Jain S, Schatz C, Le Meins JE, Earooque A, Chandraiah G, Jain AK, Misra A, Lecommandoux S (2010) The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(y-benzyl L-glutamate)-b-hyaluronan polymersomes. Biomaterials 31(10) 2882... 

Hydrogel Biomaterials Tools for Tissue Engineering and Drug Delivery. 139... 

Langer R (2000) Biomaterials in drug delivery and tissue engineering one laboratory s experience. Acc Chem Res 33 94—101... 

N. Kossovsky, A. Gelman, E. Sponsler, H. Hnatyszyn 1994, (Surface modified nanocrystalline ceramics for drug delivery application), Biomaterials 15, 1201. 

Despite the evidence for the cytotoxicity of CNTs, there are an increasing number of published studies that support the potential development of CNT-based biomaterials for tissue regeneration (e.g., neuronal substrates [143] and orthopedic materials [154—156]), cancer treatment [157], and drug/vaccine delivery systems [158, 159]. Most of these applications will involve the implantation and/or administration of such materials into patients as for any therapeutic or diagnostic agent used, the toxic potential of the CNTs must be evaluated in relation to their potential benefits [160]. For this reason, detailed investigations of the interactions between CNTs/CNT-based implants and various cell types have been carried out [154, 155, 161]. A comprehensive description of such results, however, is beyond the scope of this chapter. Extensive reviews on the biocompatibility of implantable CNT composite materials [21, 143, 162] and of CNT drug-delivery systems [162] are available. 

Arima Y, Toda M, Iwata H (2011) Surface plasmon resonance in monitoring of complement activation on biomaterials. Adv Drug Delivery Rev 63(12) 988-999... 

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