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Biological Studies Target Identification

While phenotypic screening allows for the rapid identification of biologically active molecules from a library, subsequent target identification (identification of the biological target(s) that interact with a compound of interest) is notoriously [Pg.385]

Phl(OAc)2, acetone-H20 (10 1), then primary amine, NaBH(OAc)j, CH2CI2 (h) 2,6-lutidine, NMO, OSO4 (2.5mol%), Phl(OAc)2, acetone-H20 (10 1), then NaBH4, MeOH [Pg.386]

Compound Mitotic index (Ml) EC g (pM) Growth inhibition (GDsg (pM) [Pg.387]

Growth inhibition assessed by sulforhodamine B colorimetric assay for cytotoxic effects. All values are mean standard deviation, N/A = not active. [Pg.387]

Galloway, W.R.J.D., Isidro-Llobet, A., and Spring, D.R. (2010) Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules. Nat Commun., 1, 80. [Pg.388]

See other pages where Biological Studies Target Identification is mentioned: [Pg.385] [Pg.385] [Pg.334] [Pg.335] [Pg.351] [Pg.367] [Pg.79] [Pg.75] [Pg.180] [Pg.73] [Pg.25] [Pg.137] [Pg.68] [Pg.73] [Pg.15] [Pg.22] [Pg.307] [Pg.219] [Pg.32] [Pg.43] [Pg.245] [Pg.74] [Pg.153] [Pg.150] [Pg.424] [Pg.272] [Pg.569] [Pg.580] [Pg.295] [Pg.657] [Pg.660] [Pg.109] [Pg.259] [Pg.355] [Pg.86] [Pg.1778] [Pg.1118] [Pg.344] [Pg.344] [Pg.70] [Pg.268] [Pg.57] [Pg.82] [Pg.134] [Pg.43] [Pg.215] [Pg.29] [Pg.4] [Pg.128] [Pg.67] [Pg.255]

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Biological studies

Biological targets

Target identification