Biological functional properties tissue engineering

The functions of tissue-engineered systems also need to be properly evaluated. For example, thorough biomechanical testing of polymer constructs developed for tissue engineering will be required in addition to the biological and physicochemical properties so often studied. It is not sufficient to show that a construct excels in promoting cellular attachment, proliferation, and differentiation of the desired phenotypes and has a desirable degradation profile if it cannot meet the mechanical requirements of the intended application. 

This review highlights current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury. An important role in creation of functional, biological scaffolds for tissue engineering play theirs stiffness, thermostability, porosity and dielectric properties. 

The multiscale system also appears to be capable of providing more enhanced biological functionality, particularly for vascularization, which is favored by the interaction of ECs with the nanofibrous network.s that allow suitable cell architecture and orientation for microtubule formation. Thus, the synergistic effect of micro- and nanoscales could successfully regenerate natural tissues in vivo in the near future. Future work should focus on optimizing this process to better recapitulate key features of the native ECM, including its mechanical and biochemical properties, which would enhance the functionality of these 3D multiscale scaffolds in order to fabricate functional tissue engineered constructs. 

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