Tissue engineering systems

The functions of tissue-engineered systems also need to be properly evaluated. For example, thorough biomechanical testing of polymer constructs developed for tissue engineering will be required in addition to the biological and physicochemical properties so often studied. It is not sufficient to show that a construct excels in promoting cellular attachment, proliferation, and differentiation of the desired phenotypes and has a desirable degradation profile if it cannot meet the mechanical requirements of the intended application. 

Giri, T. K., Amrita, T, Amit, A, Hemant, A. B., and Tripathi, D. K., Modified chitosan hydrogels as drug delivery and tissue engineering systems Present status and applications, Acta Pharm. Sinica B. 2 C2012], 439-449. 

Other studies have proposed coculturing cells in bioactive PA scaffolds. For example, dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHED) have been combined within PAs and investigated as a tissue-engineered system for enhancing hard and soft dental tissue regeneration. In this study, cells were cultured for up to 28 days with and without... 

According to their function in the biological environment, biomaterials can also be classified as biostable, bioabsorbable, and bioactive, and they can have applications in tissue engineering systems. 

Giri TK, Thakur A, Alexander A, Ajazuddin A, Badwaik H, Tripathi DK. Modified chi-tosan hydrogels as drug delivery and tissue engineering systems present status and applications. Acta Pharm Sin B 2012 2 439-449. 

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