Drug carriers biodegradable

Biodegradable drug carriers composed of biopolymers or hpid membrane vesicles (liposomes) can be used to formulate protein drugs in colloidal or suspension dosage forms. These biodegradable carriers can release incorporated protein in a controlled and sustained manner. 

Grislain, L. Couvreur, P. Lenaerts, V. Roland, M. Deprez-Decampeneere, D. Speiser, P. Pharmacokinetics and distribution of a biodegradable drug-carrier. Int. J. Pharm. 1983, 15, 335-345. 

Journal of Microencapsulation 17, No.5, Sept.-0ct.2000, p.625-38 5-FLUOROURACIL-LOADED CHITOSAN COATED POLYLACTIC ACID MICROSPHERES AS BIODEGRADABLE DRUG CARRIERS FOR CEREBRAL TUMOURS Chandy T Das G S Rao G H R Minnesota,University... 

Pechar M, Strohalm J, Ulbrich K, Schacht E (1997) Biodegradable drug carriers based on poly(ethylene glycol) block copolymers. Macromol Chem Phys 198 1009-1020... 

Chandy, T., Das, G.S. and Rao, G. (2000) 5-Fluorouracil-loaded chitosan coated polylactic acid microspheres as biodegradable drug carriers for cerebral tumors, J. Microencap. 17,625-38. 

Heller, J., Biodegradable polymers in controlled drug delivery, CRC Crit. Rev. Ther. Drug Carrier Syst.. 1, 39-90, 1984. 

Probably the most promising polymeric drug carrier system involves polysaccharide molecules. These are natural polymers and are often biodegradable to products that are useful to the host or easily eliminated by the host. Dextrans have been the most extensively used polysaccharide for macromolecular prodrug preparations (79). These materials are biocompatible and the in vivo fate is directly related to their molecular weight. Moreover these macromolecules can be easily targetted to the hepatocytes with D-mannose or L-fucose (20). 

The important attributes of liposomes as a drug carrier are (a) they are biologically inert and completely biodegradable (b) they pose no concerns of toxicity, antigenicity, or pyrogenicity, because phospholipids are natural components of all cell membranes (c) they can be prepared in various sizes, compositions, surface charges, and so forth, depending on the requirements of... 

Recently, many studies have focused on self-assembled biodegradable nanoparticles for biomedical and pharmaceutical applications. Nanoparticles fabricated by the self-assembly of amphiphilic block copolymers or hydrophobically modified polymers have been explored as drug carrier systems. In general, these amphiphilic copolymers consisting of hydrophilic and hydrophobic segments are capable of forming polymeric structures in aqueous solutions via hydrophobic interactions. These self-assembled nanoparticles are composed of an inner core of hydrophobic moieties and an outer shell of hydrophilic groups [35, 36]. 

M. Boisdron-Celle, J. M. Ruiz, and J. P. Benoit, Preparation and characterisation of 5-fluorouracil-loaded microspheres as biodegradable anti-cancer drug carriers, in 1992 6th International Conference on Pharmaceutical Technology, pp. 52-61. 

Macromolecules as drug carriers may be divided into degradable and nondegradable types based on their fate within the organism. Biodegradable polymeric drug carriers are traditionally derived from natural products polysaccharides, poly(amino acids) in the hope that the body s natural catabolic mechanisms will act to break down the macromolecular structure into small,... 

Liposomes are colloidal particles that can be prepared with (phospho)-lipid molecules derived from either natural sources or chemical synthesis (recently reviewed by Lian and Ho [14]). The potential application of liposomes as biodegradable or biocompatible drug carriers to enhance the potency and reduce the toxicity of therapeutic agents was recognized in 1960. In the 1960s and 1970s various methods for liposome preparation were developed as... 

The aqueous solubility of CD also enables their potential application as poly-rotaxane-based drug carriers. Yui and coworkers incorporated CD onto PEO chains in polypseudorotaxanes and polyrotaxanes [92-94], The releasing kinetics of CD from the polymer chain were studied. The release was governed by the inclusion complexation equilibrium. Biodegradation to cleave the BG units was shown to cause the release of the CD from the polyrotaxanes. 

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