Biocompatible silica nanoparticle

Biocompatible silica nanoparticles prepared by analogous sol formation followed by emulsification and doped with the antibiotic... 

Schiraldi et al. [64] have developed this kind of material by combining silica particles and pHEMA. pHEMA is a biocompatible hydrogel that has been widely studied in the past decades due to its chemical-physical structure and mechanical properties. It has been widely used in ophthalmic prostheses (contact or intraocular lenses), vascular prostheses, drug delivery systems and soft-tissue replacement [65]. These authors have shown that by incorporating silica nanoparticles, the resulting hybrid material is highly biocompatible and promotes bone cell adhesion and proliferation of bone cells seeded on it.1 ... 

NIR-absorbing metal nanostructures are appealing for biomedical imaging applications for reasons discussed previously, and this includes biological applications of SERS. For example, NIR-active core-shell superparticles have been prepared by the electrostatic assembly of densely packed Au nanoparticles on submicron silica spheres.34 Such superparticle probes can be implanted into mammalian cells by cationic transfection,186 and have produced SERS signals from absorbed DNA.187 Biocompatible SERS nanoparticle tags can also be used as contrast agents for in vivo detection, as previously discussed.169... 

Immobilized HRP in porous silica nanoparticles The preparation of silica particles under biocompatible conditions was possible when diglyceroxysilane was used as the precursor and PEG was added as a steric stabilizer. The immobilized HRP was stable for 100 days [29]... 

Wei H, Liu J, Zhou L, Li J, Jiang X, Kang J, Yang X, Dong S, Wang E (2008) Ru(bpy)3 V doped silica nanoparticles within layer-by-layer biomolecular coatings and their application as a biocompatible electrochemiluminescent tag material. Chem Eur J 14(12) 3687-3693. doi 10.1002/chem.200701518... 

He, Q. and Shi, J. 2011. Mesoporous silica nanoparticle based nano drug delivery systems Synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility. J. Mater. Chem. 21 5845-5855. Hedin, N., Graf, R., Christiansen, S.C. et al. 2004. Structure of a surfactant-templated silicate framework in the absence of 3D crystallinity. J.Am. Chem. Soc. 126 9425-9432. 

Silica, a major and natural component of sand and glass, has been employed in material sciences and engineering for many years. It is now known for a while that silica due to its versatility, biocompatibility and ease of functionalization can be a very promising candidate for gene delivery. Though, pure silica nanoparticles without surface modifications are not able to condense and deliver DNA by themselves yet they are able to enhance gene delivery in vitro by providing aide to other transfection... 

Inspired by the work of Liu and co-workers who have described a new kind of core-shell (sUica-PEG) nanoparticles as platform for dmg-delivery [71], we have very recently proposed [93] a synthetic strategy that affords monodispersed and ordered core-shell silica nanoparticles. Such systems allow the irreversible inclusion of dye molecules in the silica core and present a stable biocompatible and water soluble polymeric protective shell. For these reasons these materials appear particularly promising in the development of luminescent probes for in vitro and, hopefully, in vivo medical and bio-analytical applications. 

In particular, magnetic silica nanoparticles are of great interest for research and applications in a variety of fields because they are stable and biocompatible. With the use of an external magnet they can be isolated, treated and repeatedly utilized. In biomedical and environmental applications they have been studied and used for bio-separation, enzyme immobilization, protein purification, as magnetic resonance imaging (MRI) contrast agents, and to remove toxins or pollutants different samples. 

Trewyn, B.G., Nieweg, ).A., Zhao, Y. and lin, V.S.Y. (2008) Biocompatible mesoporous silica nanoparticles with different morphologies for animal cell membrane, penetration. Chemical Engineering Journal, 137(1), 23-9. 

Tang, F., Li, L., and Chen, D. (2012) Mesoporous silica nanoparticles synthesis, biocompatibility and drug delivery. Adv. Mater., 24, 1504-1534. 

W., Chen, L Wang, H., Mo, X., and Zhang, Y. (2013) Polyelectrolyte multilayer functionalized mesoporous silica nanoparticles for pH-responsive drug delivery layer thickness-dependent release profiles and biocompatibility. / Mater. Chem. B, 1 (43), 5886-5898. 

Thus, the hydrophilic head group and hydrophobic tail of lipids ensure assembly into the oriented bilayer array of cell membranes. The amphiphilic sheet, bilayer, and vesicle are now familiar mofits in biomimetic materials and structures. Synthetic liposomes are employed as biocompatible, biodegradable drug-delivery vehicles. Amphiphile assemblies may serve as templates mono-disperse nanoparticles are synthesized inside reverse micelles, and inorganic structures and materials such as ceramic tubules or mesoporous silica are formed around tubular micelles, rather as inorganics are patterned by vesicles in the formation of the exoskeletons of radiolarians and diatoms. 

The second hierarchical level of the nanostructure (1—4nm) can be a rather complicated stmcture. It stabilizes the nanosized carrier by modifying the surface with biocompatible coverage (polyacrylamide, silica, hydroxyapatite, titanium, or aluminum oxide, etc.). The presence of a modifying layer retains a high specific surface of the nanoparticles and allows the necessary chemical functionalization, for example, with hydroxyl, carboxyl, thiol, and amino groups. 

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