Nanoparticles bioadhesive

Behrens I, Pena A I V, Alonso M J, et al. (2002). Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats the effect of mucus on particle adsorption and transport. Pharm. Res. 19 1185-1193. 

Plapied L, Vandermeulen G, Vroman B, Preat V, Rieux A. Bioadhesive nanoparticles of fungal chitosan for oral DNA delivery. Int J Pharm. 2010 398(l-2) 210-8. 

Venugopalan P, Sapre A, Venkatesan N, and Vyas SP (2001) Pelleted bioadhesive polymeric nanoparticles for buccal delivery of insulin Preparation and characterization. Pharmazie 56 217-219. 

Yoncheva, K., Gomez, S., Campanero, M.A., Gamazo, C., Irache, J.M. (2005). Bioadhesive properties of pegylated nanoparticles. Expert Opinion on Drug Delivery, 2, 205-218. 

Pan, Y., et al. 2002. Bioadhesive polysaccharide in protein delivery system chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 249 139. 

In an effort to develop an effective bioadhesive system for buccal administration, insulin was encapsulated into polyacrylamide nanoparticles by the emulsion solvent evaporation method [98]. Though nanoparticle formation ensures even distribution of the drug, pelleting of the nanoparticles was performed to obtain three-dimensional structural conformity. In addition, it was hypothetized that the pelletized particles will remain adhered to the mucosa, leading to good absorption. While studying bioadhesion and drug release profiles, it was found that the... 

Buccal delivery for insulin has been investigated using different formulations such as buccoadhesive tablets [105], deformable vesicles [97], and pelleted bioadhesive polymeric nanoparticles [98],... 

Pan Y, Li YJ, Zhao HY, Zheng JM, Xu H, Wei G, Hao JS, Cui FD (2002) Bioadhesive polysaccharide in protein delivery system chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 249(1-2) 139-147 Park K, Robinson JR (1984) Bioadhesive polymers as platforms for oral-controlled drug delivery method to study bioadhesion. Int J Pharm 19 107-127 Patel H, Ryman BE (1981) Systemic and oral administration of liposomes. In Knight CG(ed) Liposomes From Physical Structure To Therapeutic Applications, Elsevier, Amsterdam, pp 409-441... 

Poly(alkyl-cyanoacrylates) As poly(alkyl-cyanoacrylates) form strong bonds with polar substrates including the skin and living tissues, they exhibit bioadhesive properties. These polymers are synthesized by free-radical, anionic, or zwitterionic polymerization. As detailed in a recent review, poly(alkyl-cyanoacrylate) nanoparticles are prepared by emulsion polymerization, interfacial polymerization, nanoprecipitation, and emulsion-solvent evaporation methods [102],... 

McCarron, P. A., Donnelly, R. F., Canning, P. E., McGovern, J. G., and Jones, D. S. (2004), Bioadhesive, non-drug-loaded nanoparticles as modulators of candidal adherence to buccal epithelial cells A potentially novel prophylaxis for candidosis, Biomaterials, 25(12), 2399-2407. 

Kreuter, J. (1990), Nanoparticles as bioadhesive ocular drug delivery systems, in Len-aerts, V., and Gurny, R., Eds., Bioadhesive Drug Delivery Systems, CRC Press, Boca Raton, FL, pp. 203-212. 

In another way, chitosan was used as a coating agent for nanoparticles to improve their bioadhesive properties after oral and nasal administration. Indeed, chitosan is known to have bioadhesive properties as well as an interesting absorption enhancing capacity. 

The properties of nanoparticles depend on surface morphology, specific surface area, particle size distribution, bulk density, drug incorporation, capacity, release, hydrophobicity, bioadhesiveness, and biodegradability. Nanoparticles (microspheres) loaded with the drug product can be formulated using copolymers, e.g., poly(lactide-co-glycolide) (PLG) or poly(lactide-co-ethylphosphate), by solvent extraction/evaporation technique. 

The synthesis of polyacrylic acid nanoparticles from inverse microemulsions has also been described in the literature. Polyacrylic acid is a well-known bioadhesive agent. Hence, polyacrylic acid nanoparticles loaded with the drug would have enhanced bioavailability and controlled release characteristics. The synthesis of timolol maleate and bri-monidine nanoparticles for improved ocular and oral delivery has been reported [153, 154]. 

De, T.K. and Hoffman, A.S. (2001) A reverse microemulsion polymerization method for preparation of bioadhesive polyacrylic acid nanoparticles for mucosal drug deliv. Loading and release of Timolol Maleate. Art. Cells, Blood Subst. Immob. Biotech., 29, 31-46. 

Bertholon I, Ponchel G, Labarre D (2006). Bioadhesive properties of poly(alkyl-cyanoacrylate) nanoparticles coated with polysaccharide. J. Nanosci. Nanotechnol. 6 3102-3109. 

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