Bioactivation species-specific

Table 9.III. Metabolites from deep-water marine organisms Species (specific area) Metabolites /bioactivity or technological use...

Dekant. W.. Frischmann, C.. Speerschneider, P. (1995) Sex, organ and species specific bioactivation of chloromethane by cytochrome P4502E1. Xenobiotica, 25, 1259-1265... 

Chloroform is a nephrotoxicant that most likely undergoes metabolic bioactivation within the kidney. Chloroform (CHC13), a common organic solvent widely used in the chemical industry, produces hepatic and renal injury in humans and experimental animals. Renal necrosis due to chloroform is sex- and species-specific For example, male mice exhibit primarily renal necrosis whereas female mice develop... 

Aldicarb is highly water soluble and soil application of this insecticide has the potential to result in runoff or leaching of the insecticide or active metabolites and contamination of surface or groundwater. Aldicarb is acutely toxic to bees, birds, and fish. Species-specific rates of bioactivation may influence the sensitivity of a particular organism to this insecticide. 

Rat-Specific Toxicity of Efavirenz Caused by Species-Specific Bioactivation... 

In addition to the taxonomic approach, investigating the distribution of bioactive macromolecules within the organism as well as construction and changes of algal cell wall is essential for a better understanding of environmental adaption and species-specific responses to nutritional conditions. 

The performance of the films can be further improved by co-electrodeposition with other species such as metals, nanoparticles, and carbon nanotubes. Moreover, electrodeposited sol-gel films may also serve as a platform for embedding fiuictional materials. Specifically, the sol-gel system is ideal for immobilizing bioactive species, such as enzymes and bacteria thus, electrodeposition approach allows simple one-step fobrication of biosensors. Electrodeposition also yields selective deposition of silane/CNT antireflective coatings on conductive patterns. Molecularly imprinted films are prepared by co-electrodeposition of the target molecule with sol-gel followed by its removal. 

Excitable membranes maintain and rapidly modulate substantial transmembrane ion gradients in response to stimuli 576 Specific lipid messengers are cleaved from reservoir phospholipids by phospholipases upon activation by various stimuli 576 Phospholipids in synaptic membranes are an important target in seizures, head injury, neurodegenerative diseases and cerebral ischemia 576 Some molecular species of phospholipids in excitable membranes are reservoirs of bioactive lipids that act as messengers 576 Mammalian phospholipids generally contain polyunsaturated fatty acyl chains almost exclusively esterified to the second carbon of glycerol 577... 

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