Bioabsorbable

Polydioxanone (PDS) is completely elirninated from the body upon absorption. The mechanism of polydioxanone degradation is similar to that observed for other synthetic bioabsorbable polymers. Polydioxanone degradation in vitro was affected by gamma irradiation dosage but not substantially by the presence of enzymes (39). The strength loss and absorption of braided PDS, but not monofilament PDS, implanted in infected wounds, however, was significantly greater than in noninfected wounds. 

Poly(ethylene carbonate). Like polyesters, polycarbonates (qv) are bioabsorbable only if the hydrolyzable linkages are accessible to enzymes and/or water molecules. Thus pellets of poly(ethylene carbonate), ( OCOOCH2CH2 )n weighing 200 mg implanted ia the peritoneal cavity of rats,... 

Hie ester linkage of aliphatic and aliphatic-aromatic copolyesters can easily be cleaved by hydrolysis under alkaline, acid, or enzymatic catalysis. This feature makes polyesters very attractive for two related, but quite different, applications (i) bioresorbable, bioabsorbable, or bioerodible polymers and (ii) environmentally degradable and recyclable polymers. 

Stock UA, Sakamoto T, Hatsuoka S, Martin DP, Nagashima M, Moran AM, Moses MA, Khalil PN, Schoen FJ, Vacanti JP, and Mayer JE Jr. Patch augmentation of the pulmonary artery with bioabsorbable polymers and autologous cell seeding. J Thorac Cardiovasc Surg, 2000, 20, 1158-1168. 

Schindler, A., Research Triangle Institute, Porous bioabsorb-able polyesters as controlled-release reservoirs for high molecular weight drugs, Eur. Patent Appl. EP 223708 A2, May 27, 1987. 

TH Barrows. Bioabsorbable poly(ester-amides). In SW Shalaby, ed. Biomedical Polymers Designed-to-Degrade Systems. Cincinnati, OH Hanser/Gardner, 1994, pp 97-116. 

Shawe, S., Buchanan, F., Harkin-Jones, E. and Farrar, D. (2006) A study on the rate of degradation of the bioabsorbable polymer polyglycolic acid (PGA). Journal of Materials Science, 41, 4832 4-838. 

Ormiston J, Serruys PW, Regar E, et al. A bioabsorb-able everolimus-eluting coronary stent system for patients with single de-novo coronary artery lesions (ABSORB) a prospective open-label trial. Lancet 2008 371 899-907. 

Christel, P. Li, S. M. Vert, M. Patat, J.L. (1993) Mataial for bone prosthesis containing calcium carbonate particles dispersed in a bioabsorbable polymaic matrix. Eur. Pat. Appl. EP 564,369, 6 Oct to INOTEB. Chem. Abstr., 1993, 119, 256592z. 

Bioabsorbable star polymers consisting of p-dioxanone, glycolide, and penta-erythritol were prepared by Bennett et al. (3) and used as surgical adhesives and as bone putty. 

Storey, R.F., Wiggins, J.S., Mauritz, K.A., and Puckett, A.D., Bioabsorbable composites. II Nontoxic, L-lysinebased (polyester-urethane) matrix composites. Polymer Composites 14 17, 1993. 

Grube E, Sonoda S, Ikeno E et al. Six- and twelve-month results from first human experience using everolimus-eluting stents with bioabsorbable polymer. Circulation 2004 ... 

This mechanism is applied to bioabsorbable polymer matrices in which drug elution is a function of both the matrix degradation... 

The Future of Polymer Based Bioabsorbable Drug Eluting Stents http //www.tctmd.com/csportal/appmanagerActmd/ main nfpb=true pageLabel=TCTMDContent hd Con = 1270085. 

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