Binding triazine

Detection in forest groundwater seldom occurs with the triazines due to infrequent use. In addition, forest soils are typically high in organic matter and tend to bind triazine molecules until they degrade in place. Very little nutrient leaching occurs from rich forest ecosystems due to the very active processes in place for retaining a variety of elements and compounds that would otherwise be moderately mobile (Miller and Newton, 1983). 

Among its inhibitors are methotrexate (MTX), trimethoprim, and other derivatives of pyrimidines, triazines, pteridines, and related heterocyclic compounds. Some of these inhibitors, such as MTX, bind more tightly to Escherichia coli enzyme than does the substrate dihydrofolate. This fact has been attributed to ion-pair formation between protonated MTX and a negative carboxyl, presumably Asp-27, as well as to hydrophobic interactions.33... 

Structurally related sets of triazinoquinoline, triazinoisoquinoline and pyridotriazine derivatives have been synthesized and their binding to benzodiazepine receptors studied <06EJM445>. Pyridazino[3 ,4 3,4]pyrazolo[5,l-c]-l,2,4-triazines have been prepared and their antimicrobial activity evaluated <06PS809> <06PS2505>. 

On the basis of an IR study of some s-triazines and HA systems, several authors reported that ionic bonding took place between a protonated secondary amino group of the s-triazine and a carboxylate anion on the HA [17,146,147]. Successive studies, mainly conducted by IR spectroscopy, confirmed previous results and also provided evidence for the possible involvement of the acidic phenol-OH of HA in the proton exchange of the s-triazine molecule [17, 146-150]. Differential thermal analysis (DTA) curves measured by Senesi and Testini [146, 147] showed an increased thermal stability of the HA-s-triazine complexes, thus confirming that ionic binding took place between the interacting products. 

When rats were administered atrazine in drinking water at 0.1, 0.2, or 0.5 g/1 for 1 or 3 weeks, they excreted as the principal metabolite 2 -chloro-4-ethylamino-6-amino-s-triazine. Atrazine and its metabolites have been shown to alter the activity of some testosterone-metabolizing enzymes in the rat pituitary and hypothalamus and to decrease hormone-receptor binding in the prostate. ... 

Madelmont and Veyre have reported the preparation of (206) from cyanuric chloride (75MI22002). The compound is valuable in the dynamic exploration of the lymphatic system, when it is prepared using radioactive isotopes of iodine. 2,4-Dichloro-l,3,5-triazines containing a secondary amino group with a vinylic substituent have promise in binding dental resins to biological tissues. The chlorines react with the dentine tooth enamel whilst the vinyl moiety bonds to the resin (75GEP2630745). 

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