Corticosteroid-binding globulin CBG

This structure encoding method has been applied both for the classification of a data set comprising 31 corticosteroids, for which affinity data were available in the literature, binding to the corticosteroid-binding globulin (CBG) receptor, and for the simulation of infrared spectra [28, 29). 

Kanter et al. reported an increase concentration of the corticosteroid binding globulin (CBG) (Kanter et al. 2001). Most cortisol is bound to CBG, and is biologically inactive. A greater concentration of CBG is consistent with low levels of measurable free cortisol, and provides a putative explanation for how cortisol levels could be measurably low even though other aspects of HPA axis functioning do not seem hypoactive. However, the extent to which CBG levels are a contributing cause of low cortisol requires further examination. 

Human corticosteroid binding globulin (CBG) has been the target for photoaffinity labeling by the carbene precursor, [6,7-3H]-21-diazo-21-deoxycorticosterone (Compound V)... 

Corticosteroid-Binding Globulin (CBG) is a plasma glycoprotein that binds glucocorticoids with high affinity it is responsible for transport and bioavailability of these hormones. 

McPherson, A., Mickelson, K. E. and Westphal, U. 1980. Crystallization of corticosteroid binding globulin (CBG) and alpha 1-acid glycoprotein (AAG). Journal of Steroid Biochemistry 13, 991-992. 

Hydrocortisone binds to transcortin (corticosteroid binding globulin [CBG]) and to albumii Prednisone also binds to CBG, but betamethasone, dexamethasone, and tramincinolone d... 

It is believed that it is the free non-protein-bound fraction of the circulating steroid wich is biologically active and which is metabolised. Prednisolone has been shown to bind to albumin and to specific a- and /3-globuline in plasma. Human corticosteroid-binding globulin (CBG, transcortin) binds prednisolon with a high affinity but low capacity due to relatively low concentrations of... 

Fig. 2 Regression equations should only be carried out on sets of sufficiently similar compounds otherwise the occurrence of outliers is highly likely. Here shown for the corticosteroid-binding globulin (CBG) activity of steroids. Experimental data were taken from ref 10. Left The depicted substance is the only halogen-containing molecule in this set. Right Removing this outlier from the data set yields a more consistent picture showing improved statistical quantities.

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