Cooperativity binding

El-Asmar L, Springael JY, Ballet S, Andrieu EU, Vassart G, Parmentier M. Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers. Mol Pharmacol 2005 67(2) 460-469. 

At 293 K two calcium ions bind cooperatively at the C-domain, with logK = 7.3, 7.6. 

In a recent paper, Krasnow and co-workers (120) applied a Rec A protein coating to DNA knots and catenanes to enhance visualization of the helical DNA segments and, in particular, to determine the absolute handedness of the knots. The Rec A protein is known to bind cooperatively to duplex DNA, forming a stiffened complex about 100 A in diameter in the presence of ATPase (121). 

Nichol and Winzor described the binding equations that apply to such hgand-induced changes in receptor oligomerization. They also presented the following equation to describe the joint operation of allosteric ligand binding cooperativity and receptor self-association. 

Ligand Binding Cooperativity Koshland-Nemethy-Filmer Model Scatchard Equation Ligand-Induced Conformational Change... 

LIGAND BINDING COOPERATIVITY NEGATIVE COOPERTIVITY Antiperiplanar,... 

NEGATIVE COOPERATIVITY LIGAND BINDING COOPERATIVITY Ligand occupancy,... 

LIGAND BINDING COOPERATIVE LIGAND BINDING SATURATION KINETICS Saturation ratio,... 

The relationship between the sites that bind metal ions has also been studied,1319 using 31P and 113Cd NMR spectroscopy these techniques have provided valuable information on the influence of metal-ion binding, cooperativity and phosphate binding. ... 

ATP is both a substrate and an inhibitor of the enzyme phosphofructokinase (PFK). Although the substrate fructose-6-phosphate binds cooperatively to the active site, ATP does not bind cooperatively. Explain how ATP may be both a substrate and an inhibitor of PFK. 

Supramolecular chemistry makes use of generalised coordination chemistry and binding cooperativity. 

The deoxy forms of hemocyanins are colorless, as a result of their 3d ° dicopper(I) centers. Although chemical and x-ray absorption spectroscopic studies had shed considerable light on the nature of the deoxy-He dicopper binding site, there now exist two x-ray crystal structures, the first on the the spiny lobster He, Panulirus interruptus [23], and a recent one of the horseshoe crab Limulus II protein [24], The structures exhibit rather different active-site characteristics, and since the former was crystallized at low pH and possesses rather odd copper coordination, the latter Limulus II structure is probably representative. It indicates that the two Cu(I) ions are 4.6 A apart, each found in a trigonal-planar coordination environment with Cu-NMs bond distances of about 2.0 A (Figure 1). Intersubunit 02 binding cooperative effects are probably initiated and trans-... 

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