Bezafibrate

Beverages, carbonated Beverage spirits, distilled Bexloy V Bezafibrate [41859-67-0] B. Fragilis BFR process Bglll BHA... 

Fibric Acid Derivatives. Fibtic acid derivatives have been used since the 1960s for control of blood Upid levels. The four most well-known compounds in this class ate fenofibrate, gemfibrozil, clofibrate, and bezafibrate, shown in Table 5. Fenofibrate has been the most popular fibtic acid derivative in Europe, and has mote tecentiy been investigated extensively in clinical trials in the United States (153). Bezafibrate is stmcturaHy related to clofibrate, and has tecentiy been reviewed by Western European and AustraUan clinical trials (154). 

CnH3 F204Si2) see Gemcitabine iV,0-bis(4-chlorobenzoyl)tyr amine (C22H17CI2NO5 4/859-56-7) see Bezafibrate bis(2-chloroethyl)amine (C4H9CI2N 334-22-5) see Cyclophosphamide Estramustine phosphate... 

C7H4CI2O 122-01-0) see Acemetacin Benoxaprofen Bezafibrate Feclobuzone Fenofibrate Indometacin Moclobemide Progabide Rebamipide Zomepirac (2-chlorobenzoyi)cyciopentane (C12H13CIO 6740-85-8) see Ketamine... 

Lipid regulators are ordinarily applied drugs in clinical practice, and they are used to lower the level of cholesterol and regulate the metabolism of lipids. Clara et al. [13] detected a lipid regulator bezafibrate at concentrations up to 7.6 pg L although normally they are found at lower nanograms per liter range [8,18,21,22]. 

Lipid regulators gemfibrozil and bezafibrate frequently detected in wastewaters are reported to be eliminated in WWTPs with 46-69% [51] and 36-54% [13]. On the other side, clofibric acid was reported to be refractory pollutant for municipal WWTPs [22]. 

The lipid regulator drugs bezafibrate and fenofibrate at initial concentrations of 4.5 and 4.2 ng g-1 in sterile sludge were completely removed after the fungal treatment. The fate of fenofibrate, also present in non-sterile sludge, was the same. Meanwhile, the most abundant atorvastatin, a cholesterol lowering statin, decreased its concentration in 80% and 65% in sterile and non-sterile conditions, respectively. 

Alhaique et al. [62] used a reversed phase high performance liquid chromatography method for the determination of miconazole in bulk or pharmaceuticals using bezafibrate as internal standard. 

Hayashi K, Kurushima H, Kuga Y, Shingu T, Tanaka K, Yasunobu Y, et al. Comparison of the effect of bezafibrate on improvement of atherogenic lipoproteins in Japanese familial combined hy-perlipidemic patients with or without impaired glucose tolerance. Cardiovasc Drugs Ther 1998 12 3-12. 

Yamada M. Influence of apolipoprotein E polymorphism on bezafibrate treatment response in dyslipidemic patients. J Atheroscler Thromb 1997 4 40-44. 

Fibrates, such as fenofibrate (1), gemfibrozil (2), bezafibrate (3), clofibrate (4) and ciprofibrate (5) moderately enhance HDL levels by 10-15% [17], Fibrates are... 

B13. Bimmermann, A., Boerschmann, C., Schwartzkopff, W., von Baeyer, H., and Schleicher, J., Effective therapeutic measures for reducing lipoprotein(a) in patients with dyslipidemia. Lipo-protein(a) reduction with sustained-release bezafibrate. Curr. Ther. Res. 49,635-643 (1991). B14. Black, I. W., and Wilcken, D. E. L., Decrease in apolipoprotein(a) after renal transplantation Implications for lipoprotein(a) metabolism. Clin. Chem. (Winston-Salem, NC) 38, 353-357... 

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