Furosemide Bezafibrate

Noninterfering amiloride, acebutolol, acenocoumarol, acetaminophen, aspirin, allopuri-nol, ambroxol, amoxicillin, atenolol, bendroflumethiazide, benzbromarone, bezafibrate, biperiden, bisacodyl, bromazepam, butizide, captopril, cimetidine, ciprofloxacin, clobu-tinol, clonidine, cotinine, diazepam, diclofenac, digitoxin, digoxin, dihydrocodeine, dihy-droergotamine, diltiazem, doxepin, doxycycline, enalapril, erythromycin, fenoterol, furosemide, glibenclamide, heparin, h3qjoxanthine, ibuprofen, indomethacin, isosorbide... 

Treatment with clofibrate in patients with nephrotic syndrome receiving furosemide has sometimes led to marked diuresis and severe and disabling adverse muscular effects. An isolated report describes rhabdomyolysis in a patient taking bezafibrate and furosemide. 

An isolated report attributed a case of acute renal failure and rhabdomyolysis to treatment with bezafibrate 400 mg daily and furosemide 25 mg on alternate days. ... 

Not understood. The marked diuresis may have been due to eompetition and displaeement of the furosemide by the elofibrate from its plasma protein binding sites. Clofibrate oeeasionally eauses a musele toxieity, which could have been exacerbated by the urinary loss of Na and K and the increase in the half-life of clofibrate. The reason for the bezafibrate/furo-semide-induced rhabdomyolysis is unknown. 

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