Statins Bezafibrate

The lipid regulator drugs bezafibrate and fenofibrate at initial concentrations of 4.5 and 4.2 ng g-1 in sterile sludge were completely removed after the fungal treatment. The fate of fenofibrate, also present in non-sterile sludge, was the same. Meanwhile, the most abundant atorvastatin, a cholesterol lowering statin, decreased its concentration in 80% and 65% in sterile and non-sterile conditions, respectively. 

A 67-year-old woman had ocular myasthenia while taking various statins and also bezafibrate (53). Atorvastatin had the smallest effect. 

RCTs supporting the benefits of fibrate therapy is not consistent. Gemfibrozil was used in the Helsinki Heart Study, a primary prevention trial in men with raised non-HDL-cholesterol [55], and the Veterans Administration HDL Intervention Trial, VAHIT, a secondary CVD prevention trial in men with low HDL-cholesterol and relatively normal LDL [56], These studies showed significant positive benefit for the drug overall and in diabetic subgroups. However, the populations studied in these trials also respond well to statin therapy [43], In the Bezafibrate Infarction Prevention Trial, a CVD secondary prevention trial [57], there was a trend... 

As described above, the outcome data with fibrates is mixed. Gemfibrozil is the fibrate with the best outcome data but should not be combined with a statin as it can increase plasma levels of all statins and therefore the risk of severe side effects. If the major abnormality is a high LDL-cholesterol, gemfibrozil will have little impact. Bezafibrate has a better impact on LDL as well as increasing HDL-cholesterol and decreasing triglyceride but the clinical benefits from RCTs relate only to post hoc analyses. 

LC-ESI-MS/MS has been used to determine lipid-regulating agents, including the fibrates and statins classes in water. For the fibrates, N1 mode was generally employed with deprotonated molecules [M — H] at m/z 213 for clofibric acid, m/z 249 for gemfibrozil, and m/z 360 for bezafibrate [85,87,140,147]. However, PI mode was also used for fenofibrate and bezafibrate [86]. In ESI(—) tandem MS mode, the deprotonated molecule of clofibric... 

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