Benzodiazepine halazepam

The benzodiazepines currently available for clinical use vary substantially in pharmacokinetics, acute euphoriant effects, and frequency of reported dependence. It is likely, therefore, than not all benzodiazepines have the same potential for abuse. Diazepam, lorazepam, and alprazolam may have greater abuse potential than chlordiazepoxide and clorazepate (Wolf et al. 1990). Similarly, oxazepam has been reported to produce low levels of abuse (Eliding 1978). Jaffe et al. (1983) found that in recently detoxified alcoholic patients, halazepam produces minimal euphoria even at a supratherapeutic dosage. The development of partial agonist and mixed agonist/antagonist compounds at the benzodiazepine receptor complex may offer an advantage over approved benzodiazepines for use in alcoholic patients. 

Iwata N, Cowley DS, Radel M, et al Relationship between a GABA alpha g Pro385Ser substitution and benzodiazepine sensitivity. Am] Psychiatry 156 1447—1449,1999 Jacobson AF, Dominguez RA, Goldstein B, et al Comparison of buspirone and diazepam in generalized anxiety disorder. Pharmacotherapy 5 290—296, 1985 Jaffe JH, Ciraulo DA, Nies A, et al Abuse potential of halazepam and diazepam in patients recently treated for acute alcohol withdrawal. Clin Pharmacol Ther 34 623-630, 1983... 

Halazepam Halazepam, 7-chloro-1 -(2, 2, 2 -trifluoro-1 -ethy 1)-l,3-dihydro-5-pheny 1-2//-l,4-benzodiazepin-2-one (5.1.19), also differs from diazepam in that it has a substituent on the nitrogen atom in the first position of the benzodiazepine system, which in this case is represented by the 2, 2, 2 -trifluoroethyl group. It can be made by any of the diagrams described above [13,14],... 

Benzodiazepines [P] Decreased metabolism of alprazolam, chlordiazepoxide, diazepam, halazepam, prazepam, and clorazepate but not oxazepam, lorazepam, or temazepam. 

OFFICIAL NAMES Minor tranquilizers (sedative-hyp-notics/anxiolytics)/Benzodiazepines Alprazolam (Xanax) chlordiazepoxide (Librium, Novopoxide) clonazepam (Klonopin) clorazepate (Azene, Tranxene) diazepam (Valium) estazolam (ProSom) flunitrazepam (Rohypnol/illegal in the United States) flurazepam (Dalmane) halazepam (Paxipam) lorazepam (Ativan) midazolam (Versed) oxazepam (Serax) prazepam (Centrax) quazepam (Doral) temazepam (Restoril) triazolam (Halcion)... 

Halazepam see Benzodiazepine Halcion see Benzodiazepine Haldol see Tranquilizers Haloperidol see Tranquilizers Halothane see Inhalants Halotussin DM see Dextromethorphan Hardhay see Herbal drugs Hardware see Inhalants Hash see Marijuana Hash oil see Marijuana Hashish see Marijuana Hashish oil see Marijuana Hat man see Heroin... 

The best-known and most-used anxiolytics are the benzodiazepines, of which those in use include alprazolam, bromazepam, chlordiazepoxide, clobazam, clonazepam, diazepam, flunitrazepam, halazepam, loprazolam, lorazepam, medazepam, midazolam, oxazepam, quazepam, temazepam and triazolam. The benzodiazepines work by acting as benzodiazepine binding-SITE AGONISTS at a site of the GABA receptors. 

Another consideration in the choice of benzodiazepine is their potential for abuse. Individuals with addictive disorders prefer certain agents to others. Agents with rapid onset of action, such as diazepam or alprazolam, demonstrate higher abuse potential because of their reinforcing effects. Those with slower onset of action, such as chlor-diazepoxide, oxazepam, and halazepam, are less likely to be abused. This consideration may be relevant in an outpatient setting or for patients with a history of benzodiazepine or other substance abuse. ... 

ACETOPHENAZINE, see Phenothiazines, piperazine ALPRAZOLAM, see Benzodiazepines AMITRIPTYLINE, see Tricyclic antidepressants AMOXAPINE, see Tricyclic antidepressants BENZODIAZEPINES (alprazolam, chlordiazepoxide, clorazepate, diazepam, halazepam, lorazepam, oxazepam, prazepam, temazepam)... 

Occasional Akathisia rash fever arthralgia mania aminotransferase elevations abulia alopecia Rare Extrapyramidal reactions seizures in patients with preexisting seizure disorder leukocytosis bradycardia with syncope respiratory distress FLUPHENAZINE, see Phenothiazines, piperazine HALAZEPAM, see Benzodiazepines HALOPERIDOL... 

Noggle, FT., Jr. Clark, C.R. DeRuiter, J. Liquid chromatographic separation of some common benzodiazepines and their metabolites. J.Liq.Chromatogr., 1990, 13, 4005-4021 [also alprazolam, bromazepam, chlordiazepoxide, clobazam, clorazepate, demoxepam, diazepam, estazolam, fludiazepam, fiunitrazepam, flurazepam, halazepam, lorazepam, midazolam, nitrazepam, nordiazepam, oxazepam, prazepam, temazepam, triazolam]... 

Miscellaneous Compounds - A benzodiazepine, SCH-12,041 ( , halazepam), showed evidence of efficacy against acute psychotic symptoms in an uncontrolled trial.28 CI-686 (10) was predicted to have major tranquilizer... 

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