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Hydroxylase, benzo pyrene

King DJ, MR Azari, A Wiseman (1984) Studies on the properties of highly purified cytochrome P-448 and its dependent activity benzo[a]pyrene hydroxylase, from Saccharomyces cerevisiae. Xenobiotica 14 187-206. [Pg.141]

A cytochrome P450 has been purified from Saccharomyces cerevisiae that has benzo[a]pyrene hydroxylase activity (King et al. 1984), and metabolizes benzo[fl]pyrene to 3- and 9-hydroxybenzo[fl]pyrene and benzo[fl]pyrene-7,8-dihydrodiol (Wiseman and Woods 1979). The transformation of PAHs by Candida Upolytica produced predominantly monohydroxyl-ated products naphth-l-ol from naphthalene, 4-hydroxybiphenyl from biphenyl and 3- and 9-hydroxybenzo[fl]pyrene from benzo[fl]pyrene (Cerniglia and Crow 1981). The transformation of phenanthrene was demonstrated in a number of yeasts isolated from littoral sediments and of these, Trichosporumpenicillatum was the most active. In contrast, biotransformation of benz[fl]anthracene by Candida krusei and Rhodotorula minuta was much slower (MacGillivray and Shiaris 1993). [Pg.413]

Safe (1984, 1990) described three classes of PCB congeners on the basis of their ability to induce benzo[a]pyrene hydroxylase (also known as aryl hydrocarbon hydroxylase or AHH) and ethoxyresoruhn O-deethylase (EROD) activities ... [Pg.1246]

Benzo[a]pyrene Hydroxylase Ethoxyresorufin- O-deethy lase... [Pg.1248]

Brunstrom, B. 1986. Activities in chick embryos of 7-ethoxycoumarin O-deethylase and aryl hydrocarbon (benzo[a]pyrene) hydroxylase and their induction by 3,3, 4,4 -tetrachlorobiphenyl in early embryos. Xenobiotica 16 865-872. [Pg.1324]

Fair, P.H. 1986. Interaction of benzo[a]pyrene and cadmium on GSH-S-transferase and benzo[a]pyrene hydroxylase in the black sea bass Centropristis striata. Arch. Environ. Contam. Toxicol. 15 257-263. [Pg.1399]

BENZO(a)PYRENE HYDROXYLASE (AHH) ACTIVITY OF A RECONSTITUTED MIXED-FUNCTION OXIDASE SYSTEM CONTAINING HEPATIC CYTOCHROME P-448 FROM DBA-TREATED MALE SKATES... [Pg.304]

BENZO(a)PYRENE HYDROXYLASE (AHH) AND 7-ETHOXYRESORUFIN DEETHYLASE (7-ERF) ACTIVITIES IN.LIVER HOMOGENATE OF FEMALE WINTER FLOUNDER SEPARATED INTO ARBITRARY GROUPS BASED ON AHH ACTIVITY... [Pg.314]

Bend, J. R., Hall, P., and Foureman, G. L. Comparison of benzo(a)pyrene hydroxylase (aryl hydrocarbon hydroxylase, AHH) activities in hepatic microsomes from untreated and 1,2,3,4-dibenzanthracene (DBA)-induced little skate (Raja erinacea). Bull. Mt. Desert Island Biol. Lab. (1976) 16. 3-5. [Pg.317]

Wiebel, F. J., Leutz, J. C., Diamond, L., and Gelboin, H. V. Aryl hydrocarbon (benzo[a]pyrene) hydroxylase in microsomes from rat tissues differential inhibition and stimulation by benzoflavones and orqanic solvents. Arch. Biochem. Biophys. (1971) 144 78-86. [Pg.317]

Arylhydrocarbon (benzo[a]pyrene) hydroxylase, benzphetamine-N-demethylation, ethylmorphine-N-demethylation, ethoxycoumarin-0-deethylation and ethoxyresorufin-0-deethylation were performed by published procedures (31,32,33,34), but optimized for use with trout microsomes as described previously (30, 35). Hemoprotein P-450 was determined by the procedure of Estabrook et al. (36) to avoid spectral interference by hemoglobin. Microsomal protein content was estimated either by the method of Ross and Shatz (37) or Lowry et al. (38), using bovine serum albumin standards. [Pg.321]

Initial studies designed to obtain a valid subcellular fractionation scheme for rainbow trout liver illustrated the aryl-hydrocarbon (benzo[a]pyrene] hydroxylase activity separated with glucose-6-phosphatase (35). This observation indicated that the trout hemoprotein P-450-mediated monooxygenation system was located within the endoplasmic reticulum (microsomal fraction). [Pg.322]

Payne, J.F. and Penrose, W.R. Induction of arylhydrocarbon (Benzo[a]pyrene) hydroxylase in fish by petroleum. Bull. Environ. Contam. Toxicol. (1975) 14 112-116. [Pg.334]

Haake J, Kelley M, Keys B, et al. 1987. The effects of organochlorine pesticides as inducers of testosterone and benzo(a)pyrene hydroxylases. Gen Pharmacol 18 165-169. [Pg.137]

Ghosh, D. K., Dutta, D., Samanta, T. B. Mishra, A. K. (1983). Microsomal benzo[a]pyrene hydroxylase in Aspergillus ochraceus TS Assay and characterization of the enzyme system. Biochemistry and Biophysics Research Communications, 113, 497-505. [Pg.179]

Enzyme induction experiments in male and female Wistar rats with administration of TCBT (Ugilec 141) produced a weak increase of total Cytochrome P-450 (< 1.9-fold). Benzhepthamine-AT-demethylase rose up to 3.5-fold, but benzo(a)pyrene hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) inductions were very low. Instead, the latter two inductions were markedly high with TCBT pyrolysate. TCBTs were concluded to be the pheno-barbital (PB) type of inducer, while pyrolysis products contained 3-methyl-colanthrene (3-MC) inducers of the dioxin type. The authors recommended use of TCBTs only in sealed systems [101]. [Pg.26]

Animal studies suggest that exposure to bay-region polycyclic aromatic hydrocarbons can damage the hematopoietic system leading to progressive anemia as well as agranulocytosis. Subcutaneous injection of 5 mg benz[u]anthracene daily to rats from the first day of pregnancy resulted in fetal death and resorption. Benz[c ]anthracene has been shown to induce benzo[a]pyrene hydroxylase activity in the rat placenta. [Pg.250]

Stegeman, J.J. and R.L. Binder. High benzo[a]pyrene hydroxylase activity in the marine fish Stenotomus versicolor. Biochem. Pharmacol. 28 1686-1688, 1979. [Pg.40]

Dietary pretreatment with DDT decreased the incidence of mammary tumors induced by dimethyl benzanthracene (21). Carcinogenicity of ethylene dibromide has been shown (18) to be increased by exposure to disulfiram. Induction of lung benzo(a)pyrene hydroxylase by carbaryl paralleled an Increase in lung tumors induced by benzo(a)pyrene (19). In the same experiments, pretreatment with toxaphene decreased the incidence of lung adenomas (19) and this correlated with the inhibition of lung benzo(a)pyrene hydroxylase. [Pg.124]

Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes. Biochemistry 23, 3827-3836. [Pg.236]

Gan, L.-S.L, A.L. Acebo, and W.L. Alworth (1984). 1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo(a)pyrene hydroxylase activity in liver microsomes. Biochemistry 23, 3827-3836. [Pg.298]

Figure 9.1. Sex-differences in rat hepatic microsomal drug metabolism. Data shown are based on enzyme assays in rat liver microsomes using the three indicated xenobiotic substrates ethylmorphine (EM), benzo[o] pyrene (BP), and hexobarbital (HB). Ethylmorphine A -demethylase and benzo[a]pyrene hydroxylase activities are expressed as nmol product formed per minute per mg microsomal protein, whereas hexobarbital hydroxylase activity is expressed as nmol product formed per 30 min per g liver. Also shown is hepatic microsomal total cytochrome P450 content, which is expressed as nmol per mg microsomal protein (values multiplied by 10). The data are shown as mean SD for 4 or 5 rats, except for ethylmorphine W-demethylase and total P450 which are based on a pool of 6 livers. Figure 9.1. Sex-differences in rat hepatic microsomal drug metabolism. Data shown are based on enzyme assays in rat liver microsomes using the three indicated xenobiotic substrates ethylmorphine (EM), benzo[o] pyrene (BP), and hexobarbital (HB). Ethylmorphine A -demethylase and benzo[a]pyrene hydroxylase activities are expressed as nmol product formed per minute per mg microsomal protein, whereas hexobarbital hydroxylase activity is expressed as nmol product formed per 30 min per g liver. Also shown is hepatic microsomal total cytochrome P450 content, which is expressed as nmol per mg microsomal protein (values multiplied by 10). The data are shown as mean SD for 4 or 5 rats, except for ethylmorphine W-demethylase and total P450 which are based on a pool of 6 livers.
Masaphy, S., D.C. Lamb, and S.L. Kelly (1999). Purification and characterization of a benzo(a)pyrene hydroxylase from Pleurotus pulmonarius. Biochem. Biophys. Res. Commun. 266, 326-329. [Pg.614]

See other pages where Hydroxylase, benzo pyrene is mentioned: [Pg.292]    [Pg.298]    [Pg.300]    [Pg.322]    [Pg.291]    [Pg.319]    [Pg.58]    [Pg.271]    [Pg.364]    [Pg.608]    [Pg.1873]    [Pg.17]    [Pg.194]    [Pg.190]    [Pg.125]   
See also in sourсe #XX -- [ Pg.298 , Pg.299 , Pg.300 , Pg.301 , Pg.302 , Pg.303 , Pg.304 , Pg.305 , Pg.306 , Pg.307 , Pg.308 , Pg.309 , Pg.310 , Pg.311 , Pg.312 , Pg.313 , Pg.314 ]

See also in sourсe #XX -- [ Pg.614 ]

See also in sourсe #XX -- [ Pg.112 , Pg.126 ]



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Hydroxylase, benzo pyrene hepatic microsomal

Microsomal benzo pyrene hydroxylase

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