1.2- Benzisothiazolin-3-one 1,1-dioxides

The same treatment of A-methyl(<9-methyl)arenesulfonamide (38) generates the corresponding 1,2-benzisothiazoline-3-one 1,1,-dioxide (A-methylsaccharins) (39), through triple 1,5-H shift and hydrolysis of the formed A-methyl(<9-triiodomethyl)ar-enesulfonamides [55]. This method is very useful, since biologically attractive 1,2-benzisothiazoline-3-one 1,1-dioxides bearing various kinds of substituents on the aromatic ring can be prepared under neutral conditions. 

Benzisothiazolin-3-one 1,1-dioxide benzoic sulfimide benzosulfimide l,2-dihydro-2-ketobenzisosulfonazole 2,3-dihydro-3-oxobenzisosulfonazole E954 Garantose gluside Hermesetas sacarina saccharin insoluble o-sulfobenzimide o-sulfobenzoic acid imide. 

Benzisothiazolin-3-one 1,1-dioxide, sodium salt Crystal-lose E954 sodium o-benzosulfimide soluble gluside soluble saccharin sucaryl sodium. 

The Su rez modification of the HLF reaction was the basis of the new synthetic method developed by H. Togo et al. The authors prepared A/-alkyl-1,2-benzisothiazoline-3-one-1,1-dioxides (A/-alkylsaccharins) from A/-alkyl(o-methyl)-arenesulfonamides using (diacetoxyiodo)arenes in the presence of iodine via sulfonamidyl radicals. The transformations did not work in the dark, indicating the radical nature of the reaction. The yields varied from moderate to excellent and the nature of the aromatic substituents on both the substrate and the (diacetoxyiodo)arenes were important. It should be noted that the oxygen atom at the C3 position most likely arises from the hydrolysis of a C3 diiodo intermediate (not isolated). 

Katohgi, M., Togo, H., Yamaguchi, K., Yokoyama, M. New synthetic method to 1,2-benzisothiazoline-3-one-1,1-dioxides and 1,2-benzisothiazoline-3-one-1-oxides from N-alkyl(o-methyl)arenesulfonamides. Tetrahedron 1999, 55,14885-14900. 

Ammonium 1.2-benzisothiazolin-3one 1,1-dioxide Ammonium 0-benzosulflmide Ammonium saccharin 1,2-Benzisothiazolin-3-one, 1,1-dioxide, ammonium salt Daramin EINECS 223971-8 Saccharin ammonium Saccharinale ammonium. 

Synthesis of 1,2-Benzisothiazolin-3-ones (1,1-dioxides).-from 2-(methylsulphinyl)benzaniides or N-t2-(methylthio)benzovl]-N-alkylhvdroxylamines and SOCl. Compounds (28 R=alkyl,cycloalkyl, benzyl,Ph,Ar) or (29 R=alkyl) react with SOClg to give 2-substituted 1,2-benzisothiazol-3(2H)-ones (30) nearly quantitatively. In contrast, chlorinated anilides are the major products from S0C1- and (29 R=Ar). Saccharin and analogues are pre-pared by a variety of methods ... 

Synthesis of 1,2-Benzisothiazolin-3-ones (1,1-Dioxides) 156 From 2-(methylsulphinyl)benzamides or -[2-(methylthio)benzoyl ]-fl-alkyl hydroxyl amines and SOC 156 Physical Properties of 1,2-Benzisothiazolin-3-ones 156 Reactions of 1,2-Benzisothiazolin-3-ones 156 With activated methylene compounds 156... 

Benzisothiazolin-3-one-1,1-dioxide 3-Benzisothiazolinone-1,1 -dioxide o-Benzoic acid sulfimide o-Benzosulfimide... 

Synonyms 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt 1,1-Dioxide-1,2-benzisothiazol-3(2H)-one sodium salt Saccharine soluble Saccharin sodium Saccharin, sodium salt Saccharin soluble Sodium-1,2-benzisothiazolin-3-one-1,1-dioxide Sodium benzosulfimide Sodium o-benzosulfimide Sodium 2,3-dihydro-1,2-benzisothiazolin-3-one-1,1-dioxide... 

Sodium benzenesulfonchloramide Sodium benzenesulfonchloramine. See Chloramine-B Sodium-1,2-benzisothiazolin-3-one-1,1-dioxide. See Saccharin sodium anhydrous Sodium benzoate... 

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