Behavioral effects of toxicants

Buccafiisco, J.J., Graham, J.H., Aronstam, R.S. (1988). Behavioral effects of toxic doses of soman, an organophosphate... 

These different considerations have led us to assume that this method would be useful to investigate the behavioral effects of toxicants in preference to more natural approaches such as studies in field or semi-field conditions because it allows better control of treatment and conditioning parameters. Indeed, precise quantification of behavior is essential for determining whether a specific non-environmental variable affects the normal behavior. The sublethal effects of chemical pesticides have already been studied using restrained workers in the CPE assay [32-35]. It remains to establish whether the use of the CPE response as a measure of the sub-lethal effects of chemicals on honey bees can be a reliable indicator of the hazards associated with the exposure to sublethal doses of toxic compounds, and consequently can be included in standard screening proce-... 

The determination of fhe embryonic "critical period of development" for the brain structures involved in learning and memory processes in mice is based on the original work by Rodier (1976). This study identified fhe embryonic time frames for peak neurogenesis and neuroepithelial proliferation for cerebral corfex, hippocampus, septum, amygdala, corpus striatum, thalamus, hypothalamus, cerebellum, and olfactory bulb as the period from embryonic day E14 fhrough E17. Rodier documented almost 40 years ago that the specific time of the central nervous system (CNS) insult is an important factor in subsequent effects on both anatomy and behavior. Therefore, this early work established what we refer to as the embryonic "critical period of development." The report suggested that the behavioral effects of toxicants such as benzo(a)pyrene (B(a)P) are similar in both rats and mice. This study was one of the first to demonstrate that mice could be used successfully as subjects in a variety of behavioral evaluation experiments. 

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See also in sourсe #XX -- [ ]

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