Becaplermin

Regranex Becaplermin Ortho-McNeil Lower extremity diabetic neuropathic ulcers... [Pg.695]

Regranex (becaplermin, rPDGF) Neuropathic diabetic ulcers Janssen Ortho-McNeil... [Pg.266]

Regranex , Becaplermin, rHP-DGF-BB Ortho-McNeil and Chiron Corp... [Pg.147]

Becaplermin is a recombinant human platelet derived growth factor . It is used to promote the granulation of diabetic, primarily neuropathic, chronic ulcers. Despite the low absorption and short elimination half-life, use during pregnancy and lactation is advised against. [Pg.483]

C. Hydroquinone inhibits the enzyme tyrosine kinase, which converts tyrosine to melanin. It also damages melanocytes. Becaplermin (A) is a recombinant human platelet-derived growth factor that is useful in enhancing wound healing. Etanercept (B) is a recombinant fusion protein approved for treatment of psoriatic arthritis and rheumatoid arthritis. Botulinum toxin (D) is a purified form of bofu-linum foxin fype A approved for fherapy of blepharospasm and sfrabismus. [Pg.497]

Contraindications Neoplasms at site of application, hypersensitivity to becaplermin or any component of the formulation... [Pg.119]

Tacrolimus, sirolimus, antimetabolites e.g. methotrexate, antihistaminics for pruritus dermatitis, prednicarbate (DERMATOP), becaplermin, dapsone, thalidomide, cyclosporine, interferon... [Pg.450]

A. General description Becaplermin, a recombinant human platelet-derived growth factor (rhPDGF-BB), is produced by recombinant DNA technology by insertion of the gene for the B chain of PDGF into the yeast Saccharomyces cerevisiae. [Pg.331]

Becaplermin has a molecular weight of about 25kDa and is a homodimer composed of two identical polypeptide chains bound together by disulfide bonds. [Pg.331]

Dosage form Regranex Gel is a non-sterile, preserved, sodium carboxymethyl-cellulose-based topical preparation containing becaplermin. Each gram of Regranex Gel contains becaplermin 100 pg. [Pg.331]

Cliuical pharmacology Native PDGF is a growth factor derived from blood platelets that mediates tissue repair. Becaplermin has biological activity similar to that of endogenous PDGF it promotes the chemotactic recruitment and prohfera-tion of cells involved in wound repair— fibroblasts, smooth muscle cells, monocytes, and neutrophils—and enhances the formation of granulation tissue. [Pg.332]

Drug interactions Whether becaplermin interacts with other topical medication applied to the ulcer site is not known. [Pg.332]

Other Becaplermin, PDGF, human recombinant produced in yeast, S. cerevisiae Regranex Gel Topical gel preparation, 100 Iig becaplermin/g gel Topical... [Pg.462]

Becaplermin, PDGF, human recombinant produced in yeast,... [Pg.489]

Becaplermin Diabetic neuropathic ulcers See also Chapter 41. [Pg.1306]

Becaplermin is indicated for the topical treatment of lower extremity diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond and have an adequate blood supply. [Pg.461]

Regranex Becaplermin Ortho-McNeil 12/1997 Diabetic ulcers S. cerevisiae... [Pg.1425]

Becaplermin (r-PDGF) Regranex(Chiron/N ovartis /Ortho-McNeil) Diabetic foot ulcer... [Pg.271]

Miller, M.S. Use of topical recombinant human platelet-derived growth factor-BB (becaplermin) in healing of chronic mixed arteriovenous lower extremity diabetic ulcers. J. Foot Ankle Surg. 1999, 38 (3), 227-231. [Pg.301]

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