Basal cell carcinoma Nonmelanoma skin cancer

RRM, relative risk for melanoma BCC, basal cell carcinoma NMSC, nonmelanoma skin cancer MM, malignant melanoma. 

Yiannias JA, Goldberg LH, Carter-Cambell S, et al. (1988) The ratio of basal cell carcinoma to squamous cell carcinoma in Houston, TX. J Dermatol Surg Oncol 14 886-889 Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE, Brash DE (1993) Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc Nad Acad Sci USA 90 4216-4220... 

Tumors. The two most common skin cancers are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Approximately 80 percent of nonmelanoma skin cancers are the basal cell type, and 20 percent are the squamous cell type. 

A number of trials have attempted to investigate the effect of yS-carotene supplementation on nonmelanoma skin cancer, the most common forms of which are basal cell and squamous cell carcinomas (these types of cells are both found in the top layer of the skin). However, none have shown any significant effect on skin cancer prevention. For example, the Physicians Health Study found no effect after 12 years of yS-carotene supplementation on the development of a first nomnelanoma skin cancer. The Nambour Skin Cancer Prevention Trial of 1621 men and women followed for nearly 5 years (most of whom had no history of skin cancer at baseline) showed that those supplemented with 30 mg yd-car-otene did not experience any reduction in risk of basal cell or squamous cell carcinoma or the occurrence of solar keratoses (precancerous skin growths that are a strong determinant of squamous cell... 

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