Bacteriophage morphogenesis

Kikuchi, Y., and King,J. (1975). Genetic control of bacteriophage T4 baseplate morphogenesis. III. Formation of the central plug and overall assembly pathway./. Mol. Biol. 99, 695-716. 

Wood, W. B. (1973). Genetic control of bacteriophage T4 morphogenesis. In Genetic Mechanisms of Development, ed. E. J. Ruddle. Academic Press, pp. 29 6. 

Buchwald M, Murialdo H, Siminovitch L, The morphogenesis of bacteriophage lambda, II, Identification of the principal structural proteins, Virology, 42 390-400, 1970. 

The tailspike protein from bacteriophage P22 is well suited for the second approach. The tailspike is a structural protein of P22. It is the last protein to bind to virus capsids during morphogenesis. The tailspike is also an endorhamnosidase which cleaves the 0-antigen protruding from its host cell Salmonella upon... 

In addition to the bacterial interactomes, the protein-protein interactions of the bacteriophage have been well studied using Y2H assays. About 27 proteins of the bacteriophage T7 have been studied most of these proteins are involved in the morphogenesis of the bacterial virus. 

The 11-kDa D protein of bacteriophage X plays a role in stabilizing the prohead of the phage as it fills with DNA [22,23] and is essential for head morphogenesis. D protein is assembled as trimers and appears as a protrusion on the capsid surface [24]. Sternberg and Hoess [8] have fused peptides and protein domains to the amino terminus of the D protein. They have demonstrated that the fusion protein assembles into the viral capsid and the fusion peptide is recognized by a specific monoclonal antibody. The V protein is a major tail pro-... 

Bacteriophages are also one of the most convenient materials to study macromolecular interactions. Although the host provides most of the machinery needed for the transcription and translation of the invading genome, as well as some factors for morphogenesis, many of the functions required for phage maturation are virus-specific gene products. 

Leiman PG, Kanamaru S, Mesyanzhinov VV, Arisaka F, Rossmann MG (2003) Structure and morphogenesis of bacteriophage T4. Cell Mol Life Sci 60 2356-2370... 

Marvik OJ, Jacobsen E, Dokland T, Lindqvist BH (1994) Bacteriophage P2 and P4 morphogenesis assembly precedes proteolytic processing of the capsid proteins. Virology 205 51-65... 

In the course of our examination of the morphogenesis and reproduction of viruses we shall follow the chemical principle of classification suggested by Cooper (1961), based on chemical structure of the genetic macromolecule of the virus (RNA, s ingle-stranded DNA, double-helical DNA) and their classification in accordance with the principal evolutionary groups (viruses of plants, of animals, and of bacteria). Viruses of bacteria are usually called bacteriophages. 

---