Background and Rationale

RichardB. Thompson Department of Biological Chemistry, University of Maryland School of Medicine, Baltimore, Maryland 21201. 

Topics in Fluorescence Spectroscopy, Volume 4 Probe Design and Chemical Sensing, edited by Joseph R. Lakowicz. Plenum Press, New York, 1994. 

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Part I Application Form Introduction, Background, and Rationale for Trial... 

This document describes the objectives, design, methodology, statistical considerations and organisation of a trial. Other information should be present, such as the background and rationale, for the clinical trial. It is a document key to any clinical trial. There should be a logical approach to preparing a protocol (see Box 7.2). 

B., Volkmar, F.R., Votolato, N.A., and Walson, P. (2000). Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. Background and rationale for an initial controlled study of risperidone. Child Adolesc Psychiatr Clin North Am 9 201-224. 

Richters, J.E., Arnold, L.E., Jensen, P.S., Abikoff, H., Conners, C.K., Greenhill, L.L., Hechtman, L., Hinshaw, S.P., Pelham, W.E., and Swanson, J.M. (1995) NIMH collaborative multisite multimodal treatment study of children with ADHD I. Background and rationale./ Am Acad Child Adolesc Psychiatry 34 987—1000. 

McDougle, C.J., Scahill, L., McCracken, J.T., Aman, M.G., Tierney, E., Arnold, L.E., Freeman, B.J., Martin, A., McGough, J.J., Cronin, P., Posey, D.J., Riddle, M.A., Ritz, L., Swiezy, N.B., Vitiello, B., Volkmar, F.R., Votolato, N.A., and Walson, P. (2000b) Research Units on Pediatric Psychopharmacology (RUPP) Autism Network background and rationale for an initial controlled study of risperidone. Child Adolesc Psychiatry Clin North Am 9 201—224. 

This chapter describes the background and rationale and some of the results from the first 4 years of an International Cooperative Biodiversity Group (ICBG) working in the South American nation of Suriname. Although the major focus will be on the chemistry that was carried out, the cooperative nature of the project and the importance of the results achieved in other areas demand that some account of the work of other members of the group be included. Before describing the research that was done, it will be helpful to review the overall rationale for this work. 

This chapter provides an overview of the present status of paleolimnological techniques for quantitatively inferring water chemistry from biological remains preserved in lake sediments. After presenting the background and rationale of the approach and a discussion of biotic remains in sediments, it moves to a discussion of the most recent advances for some of these groups,... 

Lunenfeld B, Saad F, Hoesl CE. ISA, ISSAM and EAU recommendations for the investigation, treatment and monitoring of late-onset hypogonadism in males scientific background and rationale. Aging Male 2005 8 59-74. 

The neurocognitive deficits in schizophrenia are considered a separate domain of the illness that is relatively independent of psychotic symptoms and closely related to functional outcome. Following the MATRICS initiative (http //www.matrics.ucla.edu), interest in this field recently increased. A description of the background and rationale for this initiative can be found in ref. 56. The following separable cognitive domains in schizophrenia were identified ... 

The boxes used throughout this document serve several purposes. Some boxes provide additional background and rationale for terms, whereas other boxes expand on concepts described in the text. The boxes at the end of each chapter highlight issues that are integral components of the risk assessment process but require more research, analysis, and debate. Further discussion of these issues is reserved for later guidelines. 

M.W. Hilgartner. The need for recombinant factor VIII historical background and rationale. Semin Hematol 1991 28(suppl l) 6-9. 

Hercberg, S., Galan, P., Preziosi, P., Roussel, A.M., Amaud, J., Richard, M.J., Malvy, D., Paul-Dauphin, A., Briancon, S., and Favier, A., Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers Supplementation en Vitamines et... 

Chapter 1 contains the background and rationale for the CEDA tool. The importance of creativity in engineering design, engineering education and the core principals of engineering design are discussed. 

The following section sets out the background and rationale for some of the main proposals in the draft Regulations. 

Clement, W.F., et a1., "Background and Rationale for Revised Military Rotor-craft Flying Qualities Specifications," Contract No. NAS2-11304, Novemeber 1983. 

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