Neurocognitive deficits

The neurocognitive deficits in schizophrenia are considered a separate domain of the illness that is relatively independent of psychotic symptoms and closely related to functional outcome. Following the MATRICS initiative (http //www.matrics.ucla.edu), interest in this field recently increased. A description of the background and rationale for this initiative can be found in ref. 56. The following separable cognitive domains in schizophrenia were identified ... 

Baseline neurocognitive deficits in the CATIE schizophrenia trial. Neuropsychopharmacology 31 2033-2046. 

Green M. 1996. What are the functional consequences of neurocognitive deficits in schizophrenia Am J Psychiatry 153 321-330. 

Green MF, Kern RS, Braff DL, Mintz J. 2000. Neurocognitive deficits and functional outcome in schizophrenia Are we measuring the right stuff . Schizophr Bull 26 119-136. 

Additionally, cacosmia, a subjective sense of altered olfactory function and feeling ill on exposure to chemical odors, which is experienced by many MCS patients, might be associated with neurocognitive dysfunction. However, MCS patients do not demonstrate a consistent or specific pattern of neurocognitive deficits and disturbances of memory and attention, which may be a result of depression and anxiety. Some have suggested that cascosmia as... 

Due to the intense therapy received by children with AML, they are at risk for a variety of long-term sequelae. A recent study reported that more than 50% of survivors have growth abnormalities. Other findings include neurocognitive deficits, transfusion-associated hepatitis, endocrine disorders, cataracts, and cardiomyopathy (median cumulative anthracychne dose 335 mg/m ). The 20-year cumulative risk for a second mahgnancy is estimated to be 1.8%. 

Krakowski MI, Czobor P, Nolan KA. Atypical antipsycho tics, neurocognitive deficits, and aggression in schizophrenic patients. J Clin Psychopharmacol 2008 28 (5) 485-93. 

---