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Drug interactions azithromycin

Clarithromycin 15 mg/kg per day in 2 doses (adult 250 mg twice daily) Diarrhea, vomiting, rash, abnormal taste, abdominal pain SJ Many drug interactions (inhibits cytochrome P-450 3A4) suspension cannot be refrigerated and has metallic taste same microbiologic issues as azithromycin... [Pg.1066]

Azithromycin Drugs that may interact with azithromycin include antacids, cyclosporine, HMG-CoA reductase inhibitors, pimozide, tacrolimus, theophyllines, and warfarin. Also consider all drug interactions with erythromycin. [Pg.1610]

Azithromycin is rapidly absorbed and well tolerated orally. It should be administered 1 hour before or 2 hours after meals. Aluminum and magnesium antacids do not alter bioavailability but delay absorption and reduce peak serum concentrations. Because it has a 15-member (not 14-member) lactone ring, azithromycin does not inactivate cytochrome P450 enzymes and therefore is free of the drug interactions that occur with erythromycin and clarithromycin. [Pg.1010]

Nahata M. Drug interactions with azithromycin and the macrolides an overview. J Antimicrob Chemother 1996 37 133-142. [Pg.83]

Westphal JF. Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4 an update focused on clarithromycin, azithromycin and dirithromycin. Br J Clin Pharmacol 2000 50 285-295. [Pg.659]

Harris S, Hilligoss DM, Colangelo PM, Eller M, Okerholm R. Azithromycin and terfenadine lack of drug interaction. Clin Pharmacol Ther 1995 58(3) 310-15. [Pg.394]

Ten Eick AP, Sallee D, Preminger T, Weiss A, Reed MD. Possible drug interaction between digoxin and azithromycin in a young child. Clin Drug Invest 2000 20 61. ... [Pg.673]

Azithromycin 250-500 mg q. 24 hr 6% No renai adjustment required No drug-drug interaction with CSA/KF NC NC NC... [Pg.921]

Which macrolide (erythromycin, clarithromycin, or azithromycin) may cause drug interactions with his current medications ... [Pg.113]

Drug interactions Erythromycin is a strong inhibitor of CYP450. CYP450 inhibition decreases with the newer maaolides. Thus, clarithromycin is a mild inhibitor, and azithromycin has no effect on aP450. [Pg.114]

Studies of the concomitant use of azithromycin with carbamazepine, terfenadine, and zidovudine have not reported drug interactions [131-133]. With the potential exception of antacids, no drug interactions have been reported with azithromycin, which does not appear to be metabolized by the cytochrome P-450 system [4, 134], Both azithromycin and clarithromycin have been associated with digoxin toxicity. The postulated mechanism is by eradication of Eubacterium lentum, an anaerobic gram-positive bacteria responsible for the metabolism of digoxin in some patients [43]. [Pg.353]

THERAPEUTIC USES Rifabutin is effective for the prevention of MAC infection in HIV-infected individuals and can decrease the frequency of MAC bacteremia. Azithromycin or clarithromycin is more effective and less likely to interact with HAART drugs. Rifabutin also is commonly substituted for rifampin in the treatment of tuberculosis in HIV-infected patients, as it has a less profound CYP-dependent drug interaction. Rifabutin also is used in combination with clarithromycin and ethambutol for the therapy of MAC disease. [Pg.794]

Clarithromycin and azithromycin are used to treat MAC and other nontuberculous mycobacteria. Clarithromycin alters the metabolism of many other drugs that are metabolized by CYPs, leading to many potential drug interactions. The broader pharmacology of these macrohdes is presented in Chapter 46. [Pg.794]

High tissue levels, prolonged half-life, and minimal liability for drug interactions are distinctive features of azithromycin... [Pg.595]

McCall KL, Anderson HG, Jones AD. Determination of the lack of a drug interaction between azithromycin and warfarin. Pharmacolhempy (2004) 24,188-94. [Pg.371]

Metabolism Erythromycin is extensively metabolized and is known to inhibit the oxidation of a number of drugs through its interaction with the cytochrome P-450 system (see p. 14). Clarithromycin is oxidized to the 14-hydroxy derivative, which retains antibiotic activity interference with the metabolism of drugs such as theophylline and carbamazepine has been reported. Azithromycin does not undergo metabolism. [Pg.330]

The effects of combining azithromycin and rifabutin have been studied in 50 subjects with or without HIV infection, of whom 19 took azithromycin 1200 mg/day and rifabutin 600 mg/day, and 31 took azithromycin 600 mg/day and rifabutin 300 mg/day (28). Neutropenia was the most common adverse event, in 33 of 50 subjects. Low-grade nausea, diarrhea, fatigue, and headache were also common, and most subjects had more than one type of event. There was no significant pharmacokinetic interaction between the two drugs. [Pg.391]

A retrospective analysis of 3995 patients treated with azithromycin did not show any pharmacokinetic interactions in patients who were also taking various other drugs, including carbamazepine (1,45). [Pg.392]


See other pages where Drug interactions azithromycin is mentioned: [Pg.1064]    [Pg.159]    [Pg.651]    [Pg.278]    [Pg.113]    [Pg.352]    [Pg.1959]    [Pg.492]    [Pg.321]    [Pg.161]    [Pg.242]    [Pg.621]    [Pg.362]    [Pg.376]    [Pg.773]    [Pg.795]    [Pg.389]    [Pg.729]    [Pg.85]    [Pg.35]    [Pg.85]    [Pg.809]   
See also in sourсe #XX -- [ Pg.353 ]




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