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Azanator, structure

Azanator (59) represents a more classical anti-histaminic structure, since the more basic nitrogen in this case occurs in the side chain. Preparation... [Pg.457]

The conformational preferences of the P(V)—N bond in four co-ordinated phosphorus compounds, Scheme 3, (11) are less pronounced, and depend more on the type of the other phosphorus substituents. However, conformations close to (12) are foimd in a variety of crystal structures of acyclic phosph(V)azanes. [Pg.92]

Although no crystal structures of cyclotriphosph(III)azanes have yet been reported, it is reasonable to assume that the ring will adopt a chair conformation and that the nitrogen atoms will have a planar or near-planar distribution of bonds. This is consistent with the structures of the six-membered ring fragments found in the cage... [Pg.103]

Cyclodipnict(III)azanes may exist as cis or trans isomers, cf. cyclodipho-sph(III)azanes (Section 11.4.1). The solid-state structures of the dichloro derivatives [ClE( i-N Bu)]2 (E = As, Sb ) reveal a cis configuration however, the derivatives [XSb(p-N Bu)]2 (X = N3, O Bu), prepared by nucleophilic substitution reactions, are isolated as trans isomers. In general, there is a trend towards the preferential formation of trans isomers in the solid state for the heavier pnictogens.In solution, however, NMR data indicate the existence of cis and trans isomers for some derivatives. In the case of the bisamido derivative [DippN(H)Sb()i-N Bu)]2, both the cis and trans isomers have been structurally characterised (Figure 11.23). ... [Pg.251]

Wheatley, P. J. X-ray diffraction determination of the crystal and molecular structure of tetramethyl-NN -bis(trimethylsilyl)-cyclodisil-azane. J. chem. Soc. [London] 1962, 1721—1724. [Pg.144]

There are several (sometimes interconvertible) cyclo-phosph(III)azanes, illustrated in Scheme 47. Bicyclic, tricyclic, adamantane cage, and more complex structures can be obtained by minor variations of the reaction conditions, also depending on the nature of the substituents at phosphorus and nitrogen sites. For reviews see Reference 214. [Pg.3732]

Nelsen and coworkers [562] detected conformational equilibria in eq, eq- and ax, eq-N, A -disubstituted cyclic hydrazines from their oxidation potentials. The anodic oxidation reactions of trans- and cw-l,3-diisopropy-l-2,4-bis(diisopropylamino)-cyclodiphospha(III)azanes are quite different [563] The trans isomer is reversibly oxidized at 0.53 V (SCE) forming a stable cation radical the c/5-isomer undergoes a completely irreversible oxidation at a more positive potential because an unstable radical cation is formed. Evans and coworkers studied structural changes associated with electron transfer reactions of W(// -C5(CH3)5)(CH3)4 and related compounds [564,565]. Yoshida and coworkers found a linear correlation on plotting the oxidation potentials of a-silylated ethers, where the rotation around the C-0 bond is restricted, against the HOMO energy-torsion angle (Si-C-O-C) curve estimated by MO calculation [566]. [Pg.1090]

Fig. 2. Crystal structure of 1,3-bis(di-tert-butylmethylsilyl)-2,2-difluoro-4,4-dimethyl-cyclodisi]azane. Table 2. Selected bond lengths and angles. Fig. 2. Crystal structure of 1,3-bis(di-tert-butylmethylsilyl)-2,2-difluoro-4,4-dimethyl-cyclodisi]azane. Table 2. Selected bond lengths and angles.
The new phosphatrane precursor (52) has been synthesized from (53) and tris(dimethylamino)phosphine, and some phosphatra-nes prepared, e.g. (54). (54) however is best prepared directly from the amine (53) and bis (dimethylamino) chlorophosphine. It is unusually stable, and removal of the proton is very difficult the structure has been confirmed by an X-ray crystal structure determination. Some cyclophosph(III)azanes (55) have been prepared as shown they contain cavities enclosed by two phosphorus atoms and two R groups which make them interesting from a coordination chemistry standpoint. The same group has... [Pg.97]

Mediator release inhibitors with antihistamine activity Several agents which are both antihistamines and inhibitors of mediator release have also been reported (Figure 12). An early compound of this type was Schering 15,280 (C, azanator) (76). Three other compounds (Cl, Cll and ClII) have subsequently been reported (TJ-SI). The most advanced of these is ketotifen (Cl) which is structurally related to azanator. It is orally active in man at 1 mg (b.i.d.) (Z7) and has been marketed by Sandoz in Switzerland. Two other potent, orally active compounds in the rat PCA procedure are Janssen s oxatomide (7 ,79) and Boehringer Mannheim s BM 15,100 (S0>S1)- These compounds combine the properties of mediator release inhibition with antihistamine activity. [Pg.61]

In principle, all radicals and ions can nowadays be named in a uniform and totally systematic manner on the basis of the operational suffixes (and prefixes derived therefrom) compiled in Table 11. Obviously, standardization of the nomenclature for such derived species can be fully congruous only if the names of the underlying parent structures themselves are generated in a thoroughly systematic way, e.g. oxidane, dioxidane, azane, diazane, etc. Hence, in the subsequent sections fully systematic names are always given as well as the conventional trivial/traditional designations. [Pg.96]

Dodds F, Garcia F, Kowenicki RA et al (2005) Synthesis and structure of the calixarene-like phosph(ni)azane macrocycle [ P(/i-N Bu) 2 l,5-(NH)2CioH6 ]3. Chem Commun 3733-3735... [Pg.441]


See other pages where Azanator, structure is mentioned: [Pg.533]    [Pg.64]    [Pg.355]    [Pg.320]    [Pg.305]    [Pg.70]    [Pg.90]    [Pg.92]    [Pg.95]    [Pg.98]    [Pg.100]    [Pg.101]    [Pg.105]    [Pg.111]    [Pg.339]    [Pg.347]    [Pg.3732]    [Pg.239]    [Pg.794]    [Pg.145]    [Pg.3731]    [Pg.113]    [Pg.381]    [Pg.305]    [Pg.33]   
See also in sourсe #XX -- [ Pg.62 ]




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