Author’s proof

Essentially new is the author s proof above of the impossibility of states of type G, which completes the theory of the detonation velocity. 

One author, generally the author to whom correspondence should be addressed, receives a proof of the manuscript for final approval before publication. Papers are not generally released for printing until the author s proof or other approval has been received. Hence, proofs should be checked and returned promptly according to individual journal or book instructions. 

My thanks are due to Dr R. F. Webb and Dr H. Goldwhite for kindly reading the book in proof. The author s grateful thanks are tendered to the numerous British and Foreign scientific and medical journals to which references have been made and from which material has been selected. Similarly the author s thanks are due to the Ministry of Supply for permission to publish certain results. 

The Author s best thanks are due to the Editor, Dr. J. Newton Friend, for his advice and for reading both the manuscript and the proofs, as well as to Miss A. R. Russell, B.Sc., A.I.C., for reading the final proofs. 

In subsequent work carried out at the combustion laboratory of the Institute of Chemical Physics, Kokochashvili showed that in the case of a mixture of bromine with hydrogen with an overabundance of hydrogen, B does not differ from unity, while with an overabundance of bromine B reaches five. This note was added by the author in proof ("1943—Editor s note). 

The literature was surveyed up to the end of 1970 some additional material on 2,1-benzisothiazoles originating from the author s laboratory and presently in course of publication has also been included. A few references to work published in 1971 have been added while this article was in proof. 

This assay is really meant to be used in experiments in which milligram quantities of lipid are available for an initial structure proof of an unknown compound. Obviously, it is not employed in lipid preparations from small quantities of cells (e.g., 2.0 X 108 cells/ml), used in signal transduction experiments. There simply is not sufficient sample for such an analysis. An alternative approach, if enough material is available, is to have a C, H, N, P analysis performed by a commercial organic analytical laboratory. As mentioned, the major difficulty is that the lipid is often a very viscous material, and this makes reproducible sampling a problem. Also, in the author s experience, the techniques used by commercial laboratories give lower-than-expected results even with synthetic saturated phospholipids. It may have to do with the combustion techniques used or unusual behavior of these compounds under assay conditions. The exact reason for this behavior is not clear. 

Complexes are frequently encountered in macromolecular chemistry. They always have the character of more or less labile compounds which can only rarely be isolated. Direct proof of their existence is difficult. By indirect proof only some of their properties are revealed, for example the ability to compete with other components during addition, a shift or change in the character of a reaction path, contribution to the overall thermodynamical parameters of the process, etc. In the author s opinion, the question of the existence of monomer complexes has not yet been fully appreciated. Work in this field should lead to important discoveries for elucidating polymerization mechanisms and kinetics, with corresponding consequences for industrial production. 

Taking the different arguments together, it is the author s opinion that the dangling bond model remains the more plausible explanation of the 2.0055 defect. Perhaps within a short time, further studies of the hyperfine interaction or calculations of the defect energy levels, etc. will be able to provide definitive proof one way or the other. In the remainder of this book, for the sake of definiteness, we refer to the 2.0055 ESR spin and the associated deep trap as the dangling bond, recognizing that the interpretation of electrical data involves only the gap state levels and the electron occupancy, not the atomic structure. 

Judging from reports in the literature and the author s experience, one would think the preparation of the Schardinger dextrin acetates would be nearly fool-proof. Even so, widely varying optical rotations and other properties have been reported for these compounds. As has been seen, the variation in optical rotations, melting points, and freezing-point depression with different dextrin preparations has led to an abundance of confusion in this area. 

Analgesic preparations are all based on one of three drugs - aspirin, paracetamol and ibuprofen - sometimes in combination with the ancillary analgesics codeine or dihydrocodeine, or with other constituents that are claimed to increase effectiveness. (Author s note please check and amend at proof stage An application has been made for P classification for naproxen for PD, and it may be reclassified before the book is published.)... 

PHOTO 20.20 (a, b, c, and cl) The vapor-proof zipper of the Level A suit shown in two views, from a distance and up close. The flap that overlays this zipper is secured by Velcro (c), and then ideally tapped with chemically resistance tape, or in this case, duck tape (d). Since the suit is vapor proof, air exhaled from the SCBA would remain within the suit and expand the suit at some point, the increased pressure would rupture the suit. This is prevented by one-way valves that allow gas (expired air) to exit the suit but prevents any outside atmosphere from entering the suit. Pictures of one valve from both outside and inside the suit (Photos 20.21 and 20.22) are provided. (Author s personal photos taken at Lakehurst, N.J. Naval Air Station. Thanks to Len Dotson, photographer and member of New Jersey Task Force 1 who spent a good deal of time serving as photographer and photographic advisor, and Sergeant Daniel Mitten of New Jersey Task Force 1 of the New Jersey State Police.)... 

PHOTO 20.29 Inside view of M40A1 mihtary negative-pressure air-purifying respirator (gas mask). Note-. The inside surface of the respirator would be in direct contact with the responder s face, and thus establish the vapor-proof water seal (derived from the responder s perspiration) between the respirator and the responder s face. When the respirator is worn by the responder, the free edge of the reversed seal would fold forward into the body of the facepiece of the respirator as the head straps are tightened by the responder. (Author s personal photograph taken by him.)... 

As the last objective, the methods of bulk drug process development will be weaved discreetly, if not seamlessly, throughout the chapter (a) the principal issues that shape the methods, (b) the most trenchant choices confronting the process development team, and (c) some selected heuristics (i.e., empirical rules that, although lacking proof, are useful often enough) distilled from the author s experience. 

About 35 years later, the Author participated in a project dealing with the design of steel skeleton structures for blast, that is, in the context of infrastructure security. Since the invented connection integrates all beams with the column and, at least partially, contributes to the spatial behavior of the entire steel skeleton structure, it should potentially provide a desired behavior during the blast contributing to the increased safety of a skeleton structure. For this reason, Urgessa and Arciszewski (2011) conducted a comparison study of the behavior of various types of connections in a steel skeleton structure under blast conditions. The Author s connection performed surprisingly well, and its behavior was comparable with a very complicated connection specifically developed for blast-resistant steel skeleton structures. It was the final feasibility proof of the developed connection. 

Photos should not be less than five X seven inches in size. Alterations of photos in page proof stage are not permitted. Each photograph or other illustration should be marked on the back, distinctly but lightly, with soft pencil, with first author s name, figure number, manuscript page number, and the side which is the top. 

Prefatory note This chapter and the others in Part II have been written in as non-mathematical a style as the author could manage. The theoretical validity of the various statements made without formal proof can be checked in any of the many available texts on Quantum Chemistry [1, 2, 3]. The initiate, who may be tempted to skip this and the following chapter, is urged to skim through them anyway. To paraphrase Shakespeare s Ulysses [8], the author s drift may be nothing to strain at but his position may not be altogether familiar . 

Finally, the author s grateful thanks are given to Miss C. King, B.Sc., for preparation of the index, for very patient proof-reading and assistance in preserving uniformity of style and also to Miss I. Ladden, B.Pharm., for compilation of manuscripts and proofs for the printers their enthusiastic help was invaluable. 

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