Atrovent - Ipratropium bromide

Atrovent (ipratropium bromide) Nasal Spray 0.03% is a metered-dose, manual-pump spray unit that delivers 21 meg (70, uL ) ipratropium bromide per spray on an anhydrous basis in an isotonic, aqueous solution with pH... [Pg.135]

The two major types of bronchodilators are the sym-padiomimetics and die xantiiine derivatives. The anticholinergic drug ipratropium bromide (Atrovent) is used for bronchospasm associated witii COPD, chronic bronchitis, and emphysema. Ipratropium is included in die Summary Drug Table Bronchodilators. Chapter 25... [Pg.334]

Ipratropium bromide (Atrovent) nasal spray is an anticholinergic agent useful in perennial allergic rhinitis. [Pg.917]

Ipratropium bromide (Atrovent) is a quaternary amine derivative that is used via inhalation in the treatment of chronic obstructive pulmonary disease and to a lesser extent, asthma. Ipratropium has a slower onset of action (1-2 hours for peak activity) than Pz-adrenoceptor agonists and thus may be more suitable for prophylactic use. Compared with p2-adrenoceptor agonists, ipratropium is generally at least as effective in chronic obstructive pulmonary disease but less effective in asthma. [Pg.464]

Atrovent inhalation solution is administered by oral inhalation with the aid of a nebulizer. It contains ipratropium bromide 0.02% (anhydrous basis) in a sterile, isotonic... [Pg.135]

Anticholinergics Atrovent (Boehringer Ingelheim) Ipratropium bromide Solution for inhalation 0.02% (500 pg/vial). In 25 unit dose vials per foil pouch. Preservative free... [Pg.234]

Atrovent HFA (BI) Ipratropium bromide November 2004 HFA 134a, purified water, dehydrated alcohol, anhydrous citric acid Solution... [Pg.692]

Rafferty P, Beasley R, Holgate ST. Comparison of the efficacy of preservative free ipratropium bromide and Atrovent nebuUser solution. Thorax 1988 43(6) 446-50. [Pg.1760]

Beasley CR, Rafferty P, Holgate ST. Bronchoconstrictor properties of preservatives in ipratropium bromide (Atrovent) nebuhser solution. BMJ (Clin Res Ed) 1987 294(6581) 1197-8. [Pg.1760]

Rafferty P, Beasley R, Holgate S T 1998 Comparison of the efficacy of preservative free ipratropium bromide and Atrovent nebuliser solution. Thorax 43 446-450 Robinson N, Derksen F, Berney C et al 1993 The ainway response of horses with recurrent airway obstruction (heaves) to aerosol administration of ipratropium bromide. Equine Veterinary Journal 25 299-303 Robinson N, Derksen F, Olszewski M 1996 The... [Pg.325]

Ipratropium Bromide. Ipratropium bromide, 3-(.Thy-droxy-l-oxo-2-phenylpnopoxy)-8-methyI-8-(l-methylethyl,-8-a/oniabicyclo[3.2.l oclanc bromide (Atrovent). is a quaternary ammonium derivative of atropine. It is freely soluM in water and ethanol but insoluble in chloroform and ether. The salt is stable in neutral and acidic solutions but lapiiU hydrolyzed in alkaline solutions. [Pg.578]

Example Ipratropium bromide (Atrovent) Route Aerosol/ Pregnancy Pharmacokinetic ... [Pg.188]

Ipratropium bromide Atrovent Inhaler release of the alkaloid Low systemic absorption Bronchodilatorin asthma... [Pg.117]

Anticholinergics — Although the precise role of anticholinergics in the treatment of asthma is not yet known, they have been advocated as an alternative to -agonist therapy in patients with cardiac arrhythmias or angina. Ipratropium bromide (14) (Sch. 1000, Atrovent ) by inhalation showed bronchodilator activity comparable with isoproterenol, but had a longer duration of action (4 hr.) with no significant side effects. ... [Pg.72]

Ipratropium bromide (ATROVENT, others) is a quaternary ammonium derivative of atropine. Oxitropium bromide is a quaternary derivative of scopolamine. Ipratropium blocks all subtypes of muscarinic receptors and thus blocks presynaptic muscarinic inhibition of ACh release. The most recently developed and bronchoselective member of this family, tiotropium bromide (spiriva), has a longer duration of action and shows some selectivity for Mj and M3 receptors, with lower affinity for receptors, and thus less presynaptic effect on ACh release. [Pg.122]

Ipratropium bromide (Atrovent) is an antichoMnergic dmg that inhibits vagal-mediated response by reversing the action of acetylchoMne, producing smooth muscle relaxation. It is a newer medication that dilates bronchioles with few systemic effects. Ipratropium bromide (Atrovent) is used five minutes before glucocorticoid (steroid) or cromolyn are inhaled so the bronchioles dilate enabling the steroids to be deposited in the bronchioles. Sometimes ipratropium bromide is combined with albuterol sulfate (Combivent) to treat chronic bronchitis for more effective and longer duration than if each is used alone. [Pg.288]

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