ATP-binding-cassette transporte

Jessup W, Gelissen IC, Gaus K, Kritharides L (2006) Roles of ATP binding cassette transporters Al and Gl, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages. Curr Opin Lipidol 17(3) 247-57... 

Figure 25-5. Metabolism of high-density lipoprotein (HDL) in reverse cholesteroi transport. (LCAT, lecithinxholesterol acyltransferase C, cholesterol CE, cholesteryl ester PL, phospholipid A-l, apolipoprotein A-l SR-Bl, scavenger receptor B1 ABC-1, ATP binding cassette transporter 1.) Prep-HDL, HDLj, HDL3—see Table 25-1. Surplus surface constituents from the action of lipoprotein lipase on chylomicrons and VLDL are another source of preP-HDL. Hepatic lipase activity is increased by androgens and decreased by estrogens, which may account for higher concentrations of plasma HDLj in women.

Chen, W, Sun, Y, Welch, C, Gorelik, A, Leventhal, AR, Tabas, I, and Tall, AR, 2001. Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes. J Biol Chem 276, 43564-43569. 

Faulkner, LE, Panagotopulos, SE, Johnson, JD, Woollett, LA, Hui, DY, Witting, SR, Maiorano, JN, and Davidson, WS, 2008. An analysis of the role of a retroendocytosis pathway in ATP-binding cassette transporter (ABCA1)—Mediated cholesterol efflux from macrophages. J Lipid Res, M800048-JLR800200. 

Kim, WS, Weickert, CS, and Gamer, B, 2008. Role of ATP-binding cassette transporters in brain lipid transport and neurological disease. JNeurochem 104, 1145-1166. 

Koldamova, RP, Lefterov, IM, Ikonomovic, MD, Skoko, J, Lefterov, PI, Isanski, BA, DeKosky, ST, and Lazo, JS, 2003. 22R-hydroxycholesterol and 9-cw-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J Biol Chem 278, 13244-13256. 

Lorenzi, I, von Eckardstein, A, Cavelier, C, Radosavljevic, S, and Rohrer, L, 2008. Apolipoprotein A-I but not high-density lipoproteins are internalised by RAW macrophages Roles of ATP-binding cassette transporter A1 and scavenger receptor BI. JMolMed 86, 171-183. 

Beta-cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages. Biochem Pharmacol 74, 256-264. 

Von Eckardstein, A, Langer, C, Engel, T, Schaukal, I, Cignarella, A, Reinhardt, J, Lorkowski, S, Li, Z, Zhou, X, Cullen, P, and Assmann, G, 2001. ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages. FASEB J 15, 1555-1561. 

B. Sjostrom et al. Correlation of gene expression of ten drug efflux proteins of the atp-binding cassette transporter family in normal human jejunum and in human intestinal epithelial caco-2 cell monolayers, /. Pharmacol. Exp. Ther. 2001, 299, 164-170... 

Hooiveld, G. J., et al. Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport. Eur. J. Pharm. Sci. 2000, 32, 13-30. 

Komatani H, Kotani H, Hara Y, Naka-gawa R, Matsumoto M, Arakawa H et al. Identification of breast cancer resistant protein/mitoxantrone resistance/pla-centa-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole stmcture. Cancer Res 2001 61(7) 2827-2832. 

Janas, E., Hofacker, M., Chen, M., Gompf, S., van der Does, C. and Tampe, R. The ATP hydrolysis cycle of the nucleotidebinding domain of the mitochondrial ATP-binding cassette transporter Mdllp. /. Biol. Chem. 278 26862-26869, 2003. 

Arakawa, R., Hayashi, M., Remaley, A. T., Brewer, B. H., Yamauchi, Y. and Yokoyama, S. Phosphorylation and stabilization of ATP binding cassette transporter Al by synthetic amphiphilic helical peptides. /. Biol. Chem. 279 6217-6220,... 

Adrenoleukodystrophy is an X-linked dysmyelinative disorder caused by mutations in the ABCD1 gene, which encodes the peroxisomal integral membrane ALD protein, a member of the ATP binding cassette transporter family. These mutations result in impaired clearance of plasma very-long-chain fatty acids. Affected males may present with symmetrical distal axonal polyneuropathy, adrenocortical insufficiency or CNS demyelination, while occasional heterozygous women demonstrate deficits suggestive of multiple sclerosis [56]. Manipulation of dietary fatty acid intake has some minimal therapeutic effect, while bone marrow transplantation has diminished deficits in a few patients. (See in Ch. 41.)... 

Hunke, S., Mourez, M., Jehanno, M., Dassa, E. and Schneider, E. (2000). ATP modulates subunit-subunit interactions in an ATP-binding cassette transporter (MalFGK2) determined by site-directed chemical cross-linking, J. Biol Chem., 275, 15 526-15 534. 

Davidson, A. L. (2002). Mechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transporters, J. Bacteriol., 184, 1225-1233. 

The role of other ABC-efHux transporters (ATP-binding cassette transporters) such as MRPs and BCRP was also intensively investigated over the past decade. However, most studies investigating the importance of ABC transporters for drug disposition were performed with different cell lines and animal models. In comparison to P-glycoprotein, only limited human data are available about the role of ABC transporters on drug disposition. In this chapter mainly human data will be discussed. For more detailed description and in vitro data about MRPs see Section 15.3. 

Stenham, D.R., Campbell, J.D., Sansom, M.S.P., Higgins, C.F., Kerr, I.D. and Linton, K.J. (2003) An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulphide cross-linking and homology modelling. FASEB Journal, 17, 2287-2289. 

T. (2006) A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions. Journal of Pharmacology... 

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