Transport hepatobiliary

Dutartre H, Bussetta C, Boretto J, Canard B (2006) General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2 -modified nucleotide analogues. Antimicrob Agents Chemother 50 4161 169 Elferink RO, Groen AK (2002) Genetic defects in hepatobiliary transport. Biochim Biophys Acta... [Pg.47]

Pauli-Magnus C, Meier PJ (2006) Hepatobiliary transporters and drag-induced cholestasis. Hepatology 44 778-787... [Pg.50]

Muller, M. and P. L. Jansen. Molecular aspects of hepatobiliary transport. Am. J. Physiol. 1997, 272, G1285-G1303. [Pg.280]

Hooiveld, G. J., et al. Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport. Eur. J. Pharm. Sci. 2000, 32, 13-30. [Pg.287]

Pagels, P., Starke, D., Kramer, W., Hepatobiliary transport of bile add amino add, bile add peptide, and bile acid oligonucleotide conjugates in rats, Hepatology 1999, 30, 1257-1268. [Pg.306]

Oude Eleerink, R., Groen, A. K., Genetic defects in hepatobiliary transport, Biochim. Biophys. Acta 2002, 1586, 129-145. [Pg.307]

Kato, Y., Akhteruzzaman, S., Hisaka, A., Sugiyama, Y., Hepatobiliary transport governs overall elimination of peptidic endothelin antagonists in rats,/. Pharmacol. Exp. Ther. 1999, 288, 568-574. [Pg.310]

Kopplow, K., Letschert, K., Konig, J., Walter, B. and Keppler, D. (2005) Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Molecular Pharmacology, 68, 1031-1038. [Pg.357]

V. Keitel, M. Burdelski, U. Warskulat, T. Kuhlkamp, D. Keppler, D. Haussinger, and R. Kubitz. Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis. Hepatology. 41 1160-1172 (2005). [Pg.394]

The best clinical evidence that BSEP is involved in hepatotoxicity is provided by human genetic studies which found four highly conserved non-synonymous mutations in two hepatobiliary transporters (BSEP and MDR3) that were specific for drug-induced liver injury [118]. Recently, a consortium of investigators identified a remarkable 82 different ABCBll mutations in 109 families that caused severe BSEP deficiency [119]. It is therefore expected that at least some of these genetic mutations and polymorphisms will put patients at an increased risk of drug-induced cholestasis. Does this justify the implementation of a simple BSEP inhibition screen for all new chemical entities The answer is not quite that simple. [Pg.368]

Pauli-Magnus, C. and Meier, P.J. (2006) Hepatobiliary transporters and drug-induced cholestasis. Hepatology (Baltimore, Md), 44 (4), 778-787. [Pg.382]

Alexander J, Aaseth J. 1981. Hepatobiliary transport and organ distribution of silver in the rat as influenced by selenite. Toxicology 21 179-186. [Pg.136]

Multi-drug resistance protein-2 (MRP-2) A protein in the bile canaliculus of liver cells involved in the hepatobiliary transport of organic chemicals. [Pg.458]

Nishida, K., Tonegawa, C., Kakutani, T., Hashida, M. and Sezaki, H. (1989) Statistical moment analysis of hepatobiliary transport of phenol red in the perfused rat liver. Pharm. Res., 6,140-146. [Pg.395]

Elferink RP, Ottenhoff R, Liefting W, et al. Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia. J Clin Invest 1989 84 476 183. [Pg.194]

Sathirakul K, Suzuki H, Yasuda K, et al. Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats. J Pharmacol Exp Ther 1993 265 1301-1312. [Pg.194]

In an in vivo study in rats, endotoxin reduced the biliary excretion of sparfloxacin and its glucuronide, probably owing to impairment of hepatobiliary transport systems and renal handling (2). [Pg.3172]

Li N, Bi YA, Duignan DB, Lai Y. Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes. Mol Pharm. 2009 6(4) 1180-1189. [Pg.75]

Kostrubsky SE, Strom SC, Kalgutkar AS, et al. Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone. Toxicol Sci. 2006 90(2) 451-459. [Pg.75]

Engelking, L.R., Anwer, M.S. Lofstedt, J. (1985) Hepatobiliary transport of indocyanine green and sulfobromophthalein in fed and fasted horses. American Journal of... [Pg.131]

Bi YA, Kazolias D, Duignan DB (2006) Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport. Drug Metab Dispos Biol Fate Chem 34 1658-1665... [Pg.116]

Prediction of Hepatobiliary Transport of Substrates from In Vitro Data... [Pg.294]

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