Asthma drug-induced

Sympathomimetics (drugs that mimic the sympathetic nervous system) are used primarily to treat reversible airway obstruction caused by bronchospasm associated with acute and chronic bronchial asthma, exercise-induced bronchospasm, bronchitis, emphysema, bronchiectasis (abnormal condition of the bronchial tree), or other obstructive pulmonary diseases. 

Aspirin-induced asthma has an onset of 30 minutes to 3 hours after ingestion. Affected individuals are cross-sensitive to all non-steroidal anti-inflammatory drugs (NSAIDs). Paracetamol is seldom associated with cross-sensitivity in patients with aspirin-induced asthma. Aspirin-induced asthma is believed to involve inhibition of COX-1. Patients should be provided with information on which drugs these are. 

Bagshaw SM, Cload B, Gilmour J, Leung ST, Bowen TJ. Drug-induced rash with eosinophilia and systemic symptoms syndrome with bupropion administration. Ann Allergy Asthma Immunol 2003 90 572-5. 

Facial swelling due to drug-induced sialadenosis was repeatedly observed in one patient who controlled her asthma symptoms with an adrenaline inhaler (SEDA-14, 119). 

Bartoli E, Faedda in Masala R, Chiandussi L. Letter Drug-induced asthma. Lancet 1976 1(7973) 1357. 

Other case reports of interest include pulmonary eosino-philia in association with montelukast (13) and the clinical exacerbation of ulcerative colitis in a patient with steroid-dependent asthma after the introduction of zafirlukast (14). Drug-induced lupus syndrome has been reported in a child with an onset 10 days after beginning treatment with zafirlukast. The child had not been taking oral glucocorticoids (15). 

Hoigne R, Braunschweig S, Zehnder D, et al. Drug-induced bronchial asthma attack epidemiological aspects (communication of CHDM Berne/St. Gallen, Switzerland). Pharmacoepidemiol Drug Saf 1994 3 S90. 

Erjefalt, I. and Persson, C.G.A. (1985). Anti-asthma drugs and capsaicine-induced microvascular effect in lower airways. Agents Actions 16, 9-10. 

Fisher HK. Drug-induced asthma syndromes. In Weiss EB, Segal MS, Stein M, eds. Bronchial Asthma Mechanisms and Therapeutics, 3d ed. Boston, Little, Brown, 1993 938-949. 

Zafirlukast (and other -lukasts ) are antagonists at LTD4 receptors with slow onset of activity (see Figure VI-1 -4) used prophylactically for many forms of asthma, including antigen, exercise, or drug induced (e.g., ASA). Adverse effects include diarrhea, headache, and increased infections. 

All NSAIDs are contraindicated in patients with active peptic ulceration and in those who have a history of hypersensitivity to any NSAID. They should be used with caution in older people (because of the risk of serious gastrointestinal side effects and drug-induced hepatitis), in allergic disorders including asthma, during pregnancy and in coagulation disorders. 

Furthermore, delavirdine (Rescriptor) is a novel HIV-1 reverse transcriptase inhibitor for HIV-positive individuals and zafirlukast (Accolate) is an anti-asthma drug. The anti-emetics ramosetron (Nasea) and dolasetron (Anzemet) are potent and highly selective 5-HTj receptor antagonists for die treatment of chemotherapy-induced nausea and vomiting. 

Kim SH, Naisbitt DJ (2016) Update on advances in research on idiosyncratic drug-induced liver injury. Allergy Asthma Immunol Res 8 3-11... 

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