Adrenal ascorbic acid

Ascorbic acid adrenal cortex depleted of ascorbic acid on production of aldosterone... 

The adrenal glands and pituitary glands have the highest tissue concentration of ascorbic acid. The brain, Hver, and spleen, however, represent the largest contribution to the body pool. Plasma and leukocyte ascorbic acid levels decrease with increasing age (152). Elderly people require higher ascorbic acid intakes than children to reach the same plasma and tissue concentration (153). 

Ascorbic acid is photosensitive and unstable in aqueous solution at room temperature. During storage of foods, vitamin C is inactivated by oxygen. This process is accelerated by heat and the presence of catalysts. Ascorbic acid concentration in human organs is highest in adrenal and pituitary glands, eye lens, liver, spleen, and brain. Potatoes, citrus fruits, blade currants, sea buckthorns, acerola, rose hips, and red paprika peppers are among the most valuable vitamin C sources [1,2]. 

Buu Hoi and Ratsimamanga116 found that kojic acid protected the adrenal ascorbic acid in test animals during the reversible period of scurvy, without itself showing vitamin C action. 

ADPGPP genes, expression of, 72 492 Adrenal glands, ascorbic acid and,... 

Biflavanoids in vegetables and fruits play a vital role in the storage of ascorbic acid in leukocytes, in the core of adrenal glands and in other organs. It also causes more effective expenses under ascorbic acid s deficiency in the organism. Phenolic compounds present in the organism, activate detoxication processes in the liver. The flavanoids exceed the tocopherols and carotenoids in terms of antioxidant effect. 

The adrenal gland and adrenergic neurons continue the synthesis by hydroxylating dopamine into norepinephrine (noradrenaline). Ascorbic acid (vitamin C see p.368) acts as a hydrogen-transferring coenzyme here. 

Ascorbic acid depleted in adrenal cortex on stimulation by ACTH Biotin and vitamin A adrenocortical insufficiency noted in biotin and vitamin A deficiency... 

Ascorbic acid may be required for steroid hormone biosynthesis depleted from adrenal cortex on cortical secretion Biotin adrenocortical insufficiency noted in biotin deficiency... 

Ascorbic acid depleted from adrenal cortex or ovary on progesterone formation Niacin diphosphopyridine nucleotide (DPN) involved in progesterone synthesis... 

Ascorbic acid was isolated from cabbage, lemon juice, and adrenal glands by Szent-Gyorgy in 1928, and identified as the antiscorbutic factor by Waugh and King in 1932. Its structure was established by Haworth and coworkers in 1933, and the same year Haworth, in Birmingham, and Reichstein, in Switzerland, succeeded in synthesizing the vitamin. 

Substances or tissue activators, such as histamine, 5-hydroxytryp-tamine, and acetylcholine, which are released in damaged tissue can stimulate the adrenal when injected directly into the adrenal blood supply. Early experiments in denervated limbs in rats suggested that the ascorbic acid depletion of the rat adrenal following injury in the isolated part was due to a humoral agent (Gl), and recent experiments show that 5-hydroxytryptamine has a direct stimulatory effect on aldosterone secretion (J7). 

---