Arteriosclerosis Insulin

Use phenylephrine 10% with caution in patients with cardiac disease, idiopathic orthostatic hypotension, hypertension, aneurysms, insulin-dependent diabetes, and advanced arteriosclerosis. 

Overall, the life span of a person, once diagnosed and treated as a diabetic, is one-third less than that of their normal fellows. While there are other candidates as causes of the major long-term complications in diabetics (neuropathy, nephropathy, retinopathy, arteriosclerosis), there is good evidence that sustained hyperglycemia, especially with reference to non-insulin-sen-sitive tissues (lens, red cells, etc.), is a prime factor in initiating and aggravating these disorders. 

The fruit body of Ganoderman lucidum (Fr.) Karst has been used for the treatment of hypertension, hyperlipidemia, arthritis, bronchitis, arteriosclerosis, diabetes and cancer. I previously reported that an aqueous extract of G lucidum reduced the elevation of blood glucose without elevating blood insulin in a test utilizing an intravenous infusion of adrenaline and an oral infusion of glucose [4], The polysaccharide... 

Chromium (Cr) is a transition element found in many compounds in the Earth s crust (Theopold 1994 Greenwood and Earn-shaw 1997). Essentiality of chromium for animals is based on its potentiation of the action of insulin. A deficiency of chromium can produce glucose intolerance and contribute to the diabetes and arteriosclerosis associated with poor glucose control (Offen-bacher et al. 1997 Anderson 1997). 

Mild D.m. can be controlled by diet, but in severe cases, insulin must be injected. Until the discovery of insulin early in this century, severe D. was invariably fatal. Milder D. is accompanied by a number of side effects, including damage to retin capillaries, cataracts, dwindling and demyelination of neuronal axons, which lead to motor, sensory and autonomic dysfunction, arteriosclerosis and renal disease. The severity of these side effects correlates directly with the degree to which blood glucose exceeds normal levels. [M. Bliss, The Discovery of Insulin, University of Chicago Press, 1982 M. Brownlee A.Cerami, Ann. Rev. Biochem. 50 (1981) 385-432 M.Hattori etal.. Science 231 (1986) 733-735]... 

Beach KW, Strandness DE Jr. Arteriosclerosis, obliterans and associated risk factors that the insulin dependent and non-insulin dependent diabetes. Diabetes 1980 29 882-888. 

Beach KW, Brunzell JD, Conquest LL, Strandness DE. The correlation of arteriosclerosis obliterans with lipoproteins in insuUn-dependent and non-insulin dependent diabetes. Diabetes 1979 28 836-840. 

Laws A, King AC, Haskell WL, et al. Relation of fasting Plasma insulin concentration to HDL-cholesterol and triglyceride concentration in men. Arteriosclerosis and Thrombosis 1991 11 1636-1642. 

Yudkin, J.S., Stehouwer, C.D.A., Emeis, J.J., and Coppack, S.W. 1999 C-reactive protein in healthy subjects Associations with obesity, insulin resistance, and endothelial dysfunction. Arteriosclerosis Thrombosis and Vascular Biology 19, 972-978. 

We also measured CRP levels in patients with diabetes. Chronic high blood sugar in diabetic patients increases the risk of arteriosclerosis. Recent studies indicate that insulin-resistant diabetes is especially correlated with arteriosclerosis and that heightened level of CRP in type 2 diabetes may be a sensitive marker of arteriosclerosis. 

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