Arsenic tumorigenicity

Calcium arsenate Pulmonary tumorigenicity demonstrated 70 weeks after 8... 

Pershagen, G. and N.E. Bjorklund. 1985. On the pulmonary tumorigenicity of arsenic trisulfide and calcium arsenate in hamsters. Cancer Lett. 27 99-104. 

ACGIH TLV TWA 0.01 mg/mh Confirmed Human Carcinogen BEL 35 n (As)/L inorganic arsenic and methylated metabolites in urine NIOSH REL CL 2 Mg(As)/mVl5M DOT CLASSIFICATION 6.1 Label Poison SAFETY PROFILE Confirmed human carcinogen with experimental tumorigenic... 

SAFETY PROFILE Confirmed human carcinogen with experimental tumorigenic data. See also ARSENIC COMPOUNDS and SELENIUM COMPOUNDS. When heated to decomposition it emits very toxic fumes of As and Se. 

OSHA PEL TWA 0.5 mg(As)/m3 ACGIH TLV BEI 35 (As)/L inorganic arsenic and methylated metabolites in urine DOT CLASSIFICATION 6.1 Label Poison SAFETY PROFILE Poison by an unspecified route. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. A skin and eye irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Used as an herbicide, defoliant, and silvicide. Hazardous when water solution is in contact with active metals, e.g., Fe, Al, Zn. When heated to decomposition it emits toxic fumes of As. 

DOT Poisonous material LD50 (oral, rat) 8 mg/kg LDLo (IV, rabbit) 6 mg/kg poison by ing. and IV routes confirmed human carcinogen tumorigen mutagen reproductive effector TSCA listed Precaution Forms arsenic acid in water Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of arsenic NFPA Health 3, Flammability 0, Reactivity 0 Storage Deliq. on exposure to air keep well closed... 

Peoples SA (1969) The failure of methanearsonic acid to cross the blood-mammary barrier when administered orally to lactating cows. Fed Proc 28 359 (abstract) Pershagen G, Bjorklund N-E (1985) On the pulmonary tumorigenicity of arsenic trioxide and calcium arsenate in hamsters. Cancer Lett 27 99-104 Pershagen G, Nordberg G, Bjorklund N-E (1984) Carcinomas of the respiratory tract in hamsters given arsenic trioxide and/or benzo(a)pyrene by the pulmonary route. Environ Res 34 227-241... 

---