Amines carcinogenicity

Nickel compounds Hydrogenations (e.g. Raney nickel) Conversion of synthesis gas to methane Reduction of organo nitro compounds to amines Carcinogenic (nickel subsulphide). Skin sensitization... 

Sellakumar AR, Montesano R, Saffiotti U. 1969. Aromatic amines carcinogenicity in hamsters. Division of Oncology. The Chicago Medical School and Eppley Inst, for Res in Cancer, University of Nebraska, Omaha, [abstract]... 

Sellakumar AR, Montesano R, Saffiotti U Aromatic amines carcinogenicity in hamsters. Proc Am Assoc Cancer Res 10 78, 1969. 

Turteltaub KW, Felton JS, Gledhill BL, et al. 1990. Accelerator mass spectrometry in biomedical dosimetry Relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA. Proc Natl Acad Sci USA 87 5288-5292. 

Lin, D., Meyer, D., Ketter, B., Lang, N., and Kadlubar, R (1994). Effects of human and rat glutathione S-transferases on the covalent DMA binding of N acctoxy derivatives of heterocyclic amine carcinogens in vitro. Cancer Res. 54,4920-4926. 

Ghoshal, A. and Snyderwine, E., Excretion of food-derived heterocyclic amine carcinogens into breast milk of lactating rats and formation of DNA adducts in the newborn, Carcinogenesis, 14, 2199, 1993. 

Turteltaub, K.W., Felton, J.S., Gledhill, B.L, Vogel, ).S., Southon, J.R., Caffee, M.W., Finkel, R.C., Nelson, D.E., Proctor, I.D., and Davis, J.C. (1990) Accelerator mass spectrometry in biomedical dosimetry relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA. Proc. Natl. Acad. Sci. USA, 87, 5288-5292. 

Toxicity screening revealed cancerogenity of some primary aromatic and heterocyclic amines [309]. According to data obtained with rodents, the mutagenicity cannot be correlated with amine carcinogenity. Health damage analysis of workers in the rubber industry has been done very carefully [310], Primary amines may not be used as stabilizers. However, some commercial stabilizers... 

Brennan, R.J and R.H. Schiestl. 1999. The aromatic amine carcinogens o-toluidine and o-anisidine induce free radicals and intrachromo-somal recombination in Saccharomyces Cere-visiae Mutat. Res. 430 37-45. 

A su ested mode of action for the inhibitory effects of CLA on the initiation of cancer forms the interference of CLA with DNA adduct formation. Effects of CLA on 2-amino-3-methylimidazo [4,5] quinoline (IQ, heterocyclic amine carcinogen) induced DNA adduct formation in different organs in rats and mice have been reported, although CLA was not successful in inhibiting adduct formation in all organs (49, 50). The inhibition of tumor growth by CLA has been attributed to the induction of lipid peroxidation in cancer cells (but not in neutral, lipid-rich tissues) (38), although work by Banni has shown that CLA does not behave differently than other polyunsaturated fatty acids (51). 

Knize, M. G., Salmon, C. R, Mehta, S. S., and Felton, J. S. 1997b. Analysis of cooked muscle foods for heterocyclic aromatic amine carcinogens. Mutat. Res. 376 129-134. 

Holder, C. L., Preece, S. W., Conway, S. C., Pu, Y. M., and Doerge, D. R. 1997. Quantification of heterocyclic amine carcinogens in cooked meats using isotope dilution liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom. 11 1667-1672. 

Eight heterocyclic aromatic amine carcinogens were extracted from cooked meats. A Cjg column and a complex 30-min 95/5- 45/55 water (lOmM triethylamine phosphate at pH 3.6)/acetonitrile resolved 2-amino-1-methyl-, 2-amino-3,8-dimethyl-, and 2-amino-3,4,8-trimethylimidazo[4,5-/]quinoxaline with monitoring by UV (A = 262 nm) and fluorescence (A = 307 nm, ex 370 nm, em). A 40-min 95/5—>-20/80 water (25 mM triethylamine phosphate at pH 3.6)/acetonitriIe gradient on the same column resolved 2-amino-1,6-dimethylimi-... 

B. N. Ames, E. G. Gurney, J. A. Miller, and H. Bartsch, Carcinogens as frameshift mutagens Metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens, Proc. Natl. Acad. Sci. U.S.A. 69, 3128-3132 (1972). 

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