Stephania japonica

Stephania japonica Miers. From the stems of this species, long used as a febrifuge in Japan, Kondo and Sanada have isolated eight alkaloids ... [Pg.361]

Stephania japonica Miers Metaphanine Ci9H23NOs (345) 232 -41°(CHC13) 15... [Pg.309]

Oxostephasunoline (4) was isolated from the roots of Stephania japonica(4). The UV spectrum of oxostephasunoline (4) showed an absorption maximum at 286 nm, and the IR spectrum depicted bands at 3550,3500, and 1670 cm, indicating the presence of a hydroxyl group and a y-lactam. The mass spectrum (Table VI) exhibited the most abundant ion peak at m/z 258, and the H-NMR spectrum (Table II) revealed the presence of three methoxyl and one N-methyl group. The downfield shift (53.06) of the JV-methyl resonance indicated that oxostephasunoline (4) was a y-lactam, which was further supported by the IR band at 1670 cm 1, significant features of the mass spectrum (Table VI), and the 13C-NMR spectrum (Table III). On exhaustive H-NMR analysis similar to the case of stephasunoline (17), the structure of oxostephasunoline (4) including the stereochemistry was practically proved (4). [Pg.329]

Oxostephabenine (15) was isolated from the fruits of Stephania japonica (7). The UV spectrum of 15 showed absorption maxima at 294 and 230 nm, and the IR spectrum depicted bands at 1700, 1680, and 1600 cm-1. Its mass spectrum revealed a molecular ion peak at m/z 493 (17%), the most abundant ion peak at m/z 241 (C14HuN03), and another significant ion peak at m/z 242 (60%, C14H12N03). The H-NMR (Table II) and 13C-NMR (Table III) spectra exhibited close similarity to those of stephabenine (13) (10) except for W-methyl resonance (7). [Pg.330]

Stephadiamine (16) was isolated as a minor component from the ethanolic extract of the whole plant of Stephania japonica collected in Taiwan (6). The IR spectrum of stephadiamine (16) exhibited bands at 3375 (NH2) and 1720 cm 1 (5-lactone), and the H-NMR spectrum (Table II) showed the presence of one JV-methyl and two methoxyl groups. Its mass spectrum revealed a base ion peak at m/z 243 of stephamiersine-type cleavage (Table V) (6). [Pg.331]

During the period 1976-1986, biosynthetic studies on hasubanan alkaloids were carried out by Battersby et al. (81-84) for hasubanonine (5) together with protostephanine (57). The two alkaloids, isolated from Stephania japonica, arise from the same precursor, and their unusual structures are of biosynthetic interest, namely, the vicinally trioxygenated ring C in 5 and the unique natural example of a dibenz d,f ] azonine skeleton in 57. [Pg.339]

Degradation of 5 and 57 revealed that both skeletons are built from two C6-C2 units derivable from tyrosine (81,82). Many 14C-labeled isoquinolines, which on biogenetic grounds could be possible late precursors of both alkaloids, were prepared and fed to Stephania japonica plants, after which the labeled alkaloids were isolated. Isoquinolines 59-64, lacking the... [Pg.341]

Stephania japonica (Thunb.) Miers. Qian Jin Teng (root) Stephanine, protostephanine, epistephanine, hypoepistephanine, homostephanoline, metaphanine, prometaphanine, hasubanonine, insularine, cyclanoline, steponine stephanoline, stepinonine.33 Treat nephritic edema, urinary tract infection, rheumatic arthritis, sciatic neuralgia. [Pg.157]

Peucedanum formosanum Hayata Stephania japonica (Thunb.) Miers. [Pg.360]

Aristolochia debilis, Stephania japonica, S. tetrandraq, S. cepharantha Abrus precatorius, Euphorbia antiquorum... [Pg.411]

Elaeagnus glabra, R. acicularis, R. amygdalifolia, R. davurica, R. koreana, R. laevigata, R. maximowicziana Epimedium brevicorum, E. koreanum, E. macranthum Stephania japonica... [Pg.421]

Harringtonine Cephalotaxus fortunei, C. qinensis, C. oliveri, C. wilsoniana, Stephania japonica... [Pg.433]

C. chlorusarca, C. dahurica, C. maximowiczii, C. pentagyna, C. pinnatifida, C. sanguinea, Hibiscus mutabilis, Persicaria amphibia, Prunella vulgaris, Vaccinium bracteatum, V. vitis-idaea Stephania japonica... [Pg.436]

Clerodendrum trichotomum, C. spicatus, Viscum album, V. coloratum Stephania japonica Marsdenia tenacissima... [Pg.453]

Stemona japonica, S. tuberosa Stemona japonica, S. tuberosa Stephania japonica Stephania japonica... [Pg.485]

Protostephanine and Hasubanonine.—The unravelling of the biosynthesis of pro-tostephanine (36) and hasubanonine (37), both produced by Stephania japonica,... [Pg.8]

In an investigation of the point of attachment of the nitrogen in the alkaloid hasubanonine from Stephania japonica, the base 254 was prepared from 14-bromocodeinone.<384)... [Pg.83]

Many dimeric piperidine alkaloids also occur in nature, e.g., carpaine which has been isolated from papaya leaves (Carica papaya) 175 the absolute configuration has been determined.176 Naturally occurring isoquinoline alkaloids177 exist in dimeric forms in some cases, e.g., the bisbenzylisoquinoline alkaloids which have two benzylisoquinoline nuclei joined together through one, two, or even three ether bridges an example is epistephanine isolated from Stephania japonica.178... [Pg.39]

Obamegine (XCIII), C36H3806N2-IfCeHe (mp 171°-173°), is a new berbamine-type alkaloid isolated from Berberis tschonoskyana Regel (44) and later from Stephania japonica Miers (71). [Pg.154]

A new oxoaporphine alkaloid is oxostephanine (38) from Stephania japonica. Imerubrine, found together with a variety of oxoaporphines and azafiuoranthenes in the South American vines Abuta imene and A. rufescens has been tentatively... [Pg.162]

Stephania japonica Liriodendron tulipifera Triclisia patens Liriodendron tulipifera Eupomatia laurina Cananga odorata Talauma mexicana ... [Pg.164]

Sinomenine, discovered by Ishiwari in Smomenium diversifolius [97], has been shown by the researches of Kondo [98] and particularly of Goto and his co-workers [99-100] to have the structure [nxvn] and to be the optical antipode of 7-methoxythebainone. It is readily converted into antipodes of substances obtainable from thebaine and codeine (see Chap. XXVI). Hasubanonine, an alkaloid isolated from Stephania japonica, is believed to be of the morphine type [101] (see Chap. XXVI). [Pg.12]

The alkaloids of stephania japonica apparently contain bases of the apomorphine group. Kondo and Sanada [96-97] have shown that desoxyepistephanine methiodide is the optical antipode of apomorphine dimethyl ether methiodide. [Pg.310]

Recently a now alkaloid obtained from Stephania japonica Miors ( hasunohaltazura ) has boon investigated and shown to be very... [Pg.357]

Stephania japonica (Thunb.) Miers (Menispermaceae)[also called Coccuius Japonicus (Menispermaceae)][263,264]... [Pg.19]

Stephania Japonica (Thunb.) Miers var australis (Menispeimaceae) 4S8] Stephania sutchuenensis H.S. Lo (Menispennaceae) 459]... [Pg.52]

See also in sourсe #XX -- [ Pg.144 , Pg.347 , Pg.408 , Pg.422 , Pg.440 ]

See also in sourсe #XX -- [ Pg.83 , Pg.144 ]

See also in sourсe #XX -- [ Pg.154 ]

See also in sourсe #XX -- [ Pg.6 , Pg.480 ]

See also in sourсe #XX -- [ Pg.484 ]

See also in sourсe #XX -- [ Pg.4 , Pg.222 , Pg.223 ]

See also in sourсe #XX -- [ Pg.222 , Pg.223 ]

See also in sourсe #XX -- [ Pg.173 , Pg.202 ]

See also in sourсe #XX -- [ Pg.454 ]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...