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Applications of the Amination Chemistry

Studies on the applications of the amination chemistry have begun to emerge. These results demonstrate the utility of the amination in the construction of complex, biologically active molecules, in the synthesis of electronically important structures, and in the synthesis of ligands for other catalytic chemistry. [Pg.228]

An interesting application of the amination in carbohydrate chemistry has been reported by Buchwald and Seeberger [217]. In this work, the amination chemistry was used as a de-... [Pg.140]

N-Boc-N-(but-2-enoyl)amine is an excellent pronucleophile for the Ir-catalyzed allylic amination under salt-free conditions (cf. Table 9.3, entries 15-18). The products were subjected to RCM with good results, even upon application of the Grubbs I catalyst (Scheme 9.29) [27bj. The resultant N-Boc protected a,P-unsaturated y-lactams are valuable chiral intermediates with appUcations in natural products synthesis and medicinal chemistry. [Pg.238]

Several reports on the application of the intermolecular arylation of primary alkylamines have appeared. For example, the reaction of primary amines with chloro 1,3 azoles has been used to produce the H-l-antihistaminic norastemizole [153]. As shown in Eq. (32), the palladium chemistry is dictated by the steric properties of the amines. This property creates selectivity that complements the thermal chemistry, which is dictated by amine nucleophilicity. These researchers have also shown that this high selectivity for arylation of primary over secondary amines with catalysts containing BINAP as ligand allows for the rapid assembly of other multiamino-based structures [154]. [Pg.230]

The amination of aryl halides and triflates catalyzed by palladium complexes is suitable for use in complex synthetic problems. Many substrates will produce high yields of mixed arylamines with one of the existing catalyst systems. Nevertheless, there are many combinations of substrates for which the amination chemistry may be substantially improved. For the most part, these reactions involve nitrogen centers, such as those in pyrroles, indoles, amides, imidazoles and other heterocyclic groups that are less basic than those in standard alkylamines. Although mild reaction conditions have been developed for many substrates, the harsh conditions used in many of the applications indicate that continued studies on developing mild condi-... [Pg.257]

In this review we focus on applications of the LFDFT method to complexes of 3d metals and compare these with both spectral data from well documented sources [1, 2] and other theoretical methods, such as the spectroscopically oriented Cl (SORCI) method [7] and time-dependent density-functional theory (TDDFT) [8-17]. In particular we intend to emphasize applications to systems with atypical electronic properties of interest for bio-inorganic chemistry and homogeneous catalysis. These systems include macrocyclic amines of Fe in various oxidation states, which are of interest for enzymatic and catalytic reactivity both for redox and bond-breaking reactions. [Pg.412]


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The Amines

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