Applications of mass spectrometry

Understanding Bioanalytical Chemistry. Principles and applications Victor A. Gault and Neville H. McClenaghan 2009 John Wiley Sons, Ltd 

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In many applications of mass spectrometry, it is necessary to obtain a mass spectrum from a sample dissolved in a solvent. The solution cannot be passed directly into the mass spectrometer because, in the high vacuum, the rapidly vaporizing solvent would entail a large pressure increase, causing the instrument to shut down. 

Reed, R.I., Applications of Mass Spectrometry to Organic Chemistry, Academic Press, New York, 1966. Schlag, E.W., ZEKE Spectroscopy, Cambridge University Press, London, 1998. 

Suelter, C.H. and Watson, J.T., Biomedical Applications of Mass Spectrometry, Wiley Interscience, New York, 1990. 

The mass spectrometry of fluonnated organic compounds was reviewed in 1961 [55], and this review should be consulted for information on the applications of mass spectrometry in organofluorine chemistry up to that time With the advent of... 

Application of mass spectrometry for the analysis of tautomeric compounds... 

A number of reviews of mass spectra of carbohydrates have been published from which references to the original papers are available (4, 9, 11, 24, 26). The application of mass spectrometry to this field was initially limited by the relatively low volatility of free carbohydrates and by the complex spectra obtained from some derivatives. These limitations have been partially overcome by new inlet techniques and by pioneering studies on classes and derivatives in order to understand the characteristic fragmentations and rearrangements of the molecular ions of a wide range of carbohydrates. 

Commercial Instruments Because of the proliferation of applications of mass spectrometry in organic and analytical chemistry, there are instruments marketed by numerous companies today. Some of the popular ones are the low resolution, single focusing model 21-490 and the high resolution, double focusing models, 21-492 and 21-110 of Du Pont de Nemours Co, and the double focusing model MS-9 of Associated Electrical Industries... 

R.I. Reed, Applications of Mass Spectrometry to Organic Chemistry , Academic Press,... 

Halverson J. 1984. A review of application of mass spectrometry to low-level radionuclide metrology. Nucl Instrum Methods Phys Res 223 349-355. 

Application of mass spectrometry to analysis of additives in polymers is mainly used as a qualitative tool and relates to three main areas ... 

Gas and liquid chromatography directly coupled with atomic spectrometry have been reviewed [178,179], as well as the determination of trace elements by chromatographic methods employing atomic plasma emission spectrometric detection [180]. Sutton et al. [181] have reviewed the use and applications of ICP-MS as a chromatographic and capillary electrophoretic detector, whereas Niessen [182] has briefly reviewed the applications of mass spectrometry to hyphenated techniques. 

Suzuki, K. Application of mass spectrometry to bacterial taxonomy. Cellular fatty acids and isoprenoid quinones. Iyo Masu Kenkyukai Koenshu 1987,12,45-53. 

Drucker, D. B. Jenkins, S. A. Applications of mass spectrometry including combined gas chromatography-mass spectrometry in taxonomic studies of bacteria. Biochem. Soc. Trans. 1989,17, 245-249. 

Almost all applications of mass spectrometry in biochemistry and biomedicine require preparation of the samples prior to MS analysis. Sample preparation typically includes a number of steps to purify and concentrate target biomarker analytes. However, heme crystal formation, a unique evolutionary... 

I. Lavagnini, F. Magno, R. Seraglia and P. Traldi, Quantitative Applications of Mass Spectrometry, Chichester, J. Wiley Sons, 2006. 

L. Ogunkoya, Application of mass spectrometry in structural problems in triterpenes, Phytochem., 20, 121 126 (1981). 

In this respect, research relies heavily on structural information at a molecular level, and thus the application of mass spectrometry plays a prominent role. This is mainly due to its... 

Stobiecki M. 2000. Application of mass spectrometry for identification and structural studies of flavonoid glycosides. Phytochemistry 54(3) 237-256. 

J. Oro and D. Nooner, Cosmochemical and Geochemical Application of Mass Spectrometry , in Practical Mass Spectrometry (Ed. B. S. Middleditch), 2nd edn., Plenum Press, New York and London, 1981, pp. 327-359. 

Instrumentation. Principle of Mass Spectrometry. Characteristics and Interpretation of Molecular Mass Spectra. Applications of Mass Spectrometry. 

J. S. Sphtter and F. Turecek (eds.) Application of Mass Spectrometry to Organic Stereochemistry. New York VCH Pubhshers, 1994. 

Sastry, S.D., Buck, K.T., Janak, J., Dressier, M. Preti, G. (1980) Volatiles emitted by humans. In G.R. Waller and O.C.Dermer (Eds.), Biochemical Applications of Mass Spectrometry, First Supplementary Volume. John Wiley, New York, pp. 1086-1129. 

Most compounds can be detected directly as they are able to produce a direct analytical signal. Photometric detection, especially UV (including diode array and multi-wavelength UV detection) is by far the most frequently applied detection technique. The application of mass spectrometry (MS) detection in CE is attractive as it can provide structural information [44]. Hologram-based refractive index detection [45] and electrochemical detection [46,47] were also reported. Conductivity [41,48-50] and amperometric [51,52] detection has shown to have advantages for the analysis of both organic and inorganic compounds. 

The peak clue to molecular ion is referred as M+ peak and its mass corresponds to the molecular weight. The first analytical application of mass spectrometry was described in 1940 when mass spectrometers of good quality became commercially available. 

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