Apoptosis, psoralen

Viola, G., Racdolo, L., Vedaldi, D., Disaro, S., Basso, G. and Dall Acqua, R. (2004) Differential response of linear and angular psoralens in PUVA-induced apoptosis in HL-60 cells. Photochem. Photobiol. Sci., 3, 237-9. 

In the final chapter, Gambari et aL summarize the structure and biological effects of furocoumarins. The authors mainly focus on linear and angular psoralens. Borrowing from their laboratory experiences, they describe the interesting biological effects of such compounds on cell cycle, apoptosis and differentiation as well as their use for the treatment of j6-thalassemia. 

Radical prodnction is the essence of the action of certain drugs, some antibiotics, and psoralens they may be activated by UV light, while the male contraceptive gossipol acts via ROS formation, the ROS damaging the spermatozoa motility (Bartosz, 1995). Becanse ROS induce apoptosis, they are experimented with in selective killing of cancer cells (Sen et al., 1998 Heimli et al., 2001)... 

Decreased epidermal proliferation is considered to be the main mechanism of action of PUVA in the treatment of psoriasis. Once excited by UVA, psoralens can react with molecular oxygen, producing reactive oxygen species that cause mitochondrial dysfunction and lead to apoptosis of skin Langerhans cells, keratinocytes, and lymphocytes [134]. PUVA further decreases epidermal cell proliferation by noncompetitively binding to epidermal growth factor receptors and directly altering the cell surface membrane. 

The therapeutic effect of ECP for GVHD appears to involve induction of apoptosis in psoralen plus UVA-exposed lymphocytes, modulation of monoc3de-derived dendritic cell differentiation, increased production of antiinflammatory cytokines, decreased dendritic cell antigen-presenting function, and induction of regulatory T cells that establish immune tolerance [200,201]. 

Psoralen Photolysis Photoadduct Formation with Biomolecules Apoptosis... 

In the last decade, the involvement of apoptosis in PUVA and in photopheresis strongly stimulated research in this field. A recent paper reports that mitochondria represent an important target psoralen photoinduced apoptosis. ... 

Efferth, T., Fabry, U., and Osieka, R., Induction of apoptosis, depletion of glutatione, and damage by extracorporeal photochemotherapy and psoralen with exposure to UV light in vitro. Anticancer Res., 21, 2777, 2001. 

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