Apoptosis mustard-induced

Dahrowska, M.I., Becks, L.L., Lelli, J.L., Jr., Levee, M.G., Hinshaw, D.B. (1996). Sulfm mustard induces apoptosis and necrosis in endothelial cells. Toxicol. Appl. Pharmacol. 141 568-83. 

Kan, R.K., Pleva, C.M., Hamilton, T.A., Anderson, D.R., Petrali, J.P. (2003). Sulfur mustard-induced apoptosis in hairless guinea pig skin. Toxicol. Pathol. 31 185-90. 

Sourdeval, M., Lemaire, C., Deniaud, A., Taysse, L., Daulon, S., Breton, P., Brenner, C., Boisvieux-Ulrich, E., Marano, F. (2006). Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 11 1545-59. 

Rosenthal DS, Simbulan-Rosenthal CM, Iyer S, Spoonde A, Smith W, Ray R, Smulson ME. 1998. Sulfur mustard induces markers of terminal differentiation and apoptosis in keratinoc3des via a Ca -cahnodulin and caspase-dependent pathway. J Invest Dermatol 111 64—71. 

Smith KJ, Graham JS, Hamilton TA et al. (1997). Immunohistochemical studies of basement membrane proteins and proliferation and apoptosis markers in sulfur mustard induced cutaneous lesions in weanling pigs. J Dermatol Sci, 15, 173-182. 

Rosenthal, D.S., Velena, A. et al. (2003). Expression of dominantnegative Fas-associated death domain blocks human kerati-noc 4e apoptosis and vesication induced by sulfur mustard. J. Biol. Chem. 278 8531 0. 

Calmodulin, poly(ADP-ribose)polymerase and p53 are targets for modulating the effects of sulfur mustard (Rosenthal et al, 2000). It was tested whether calmodulin mediates the mitoehondrial apoptotic pathway induced by SM in human keratinoeytes. Of the three human CaM genes, the predominant form expressed was CaMl. These results indicate that CaM, ealeineurin, and Bad also play a role in SM-induced apoptosis, and may therefore be targets for therapeutic intervention to reduce SM injury (Simbulan-Rosenthal et al, 2006). 

Han, S., Espinoza, L.A., Liao, H., Boulares, A.H., Smulson, M.E. (2004). Protection by antioxidants against toxicity and apoptosis induced by the sulphur mustard analogue 2-chloroethylethyl sulphide (GEES) in Jurkat T cells and normal human lymphocytes. Br. J. Pharmacol. 141 795-802. 

Levitt, J.M., Lodhi, I.J., Nguyen, P.K., Ngo, V., Clift, R., Hinshaw, D.B., and Sweeney, J.F. (2003). Low-dose sulfur mustards primes oxidative function and induces apoptosis in human polymorphonuclear leukocytes. Int Immunopharmacol 3, 747-56. 

D. S. Rosenthal, A. Velena, F. P. Chou, R. Schlegel, R. Ray, B. Benton, D. Anderson, W. J. Smith and C. M. Simbulan-Rosenthal, Expression of dominant-negative Fas-associated death domain blocks human kera-tinocyte apoptosis and vesication induced by sulfur mustard, /. Biol Chem., 2003,278, 8531-8540. 

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