Hypoxia induced apoptosis

In studies in vitro, caspases are involved in hypoxic [62,64] injury to RTE cells. Antimycin A-induced chemical hypoxia [64] or growth under hypoxic conditions results in increased caspase activity and pancaspase inhibition prevents hypoxia-induced DNA fragmentation and cell death in RTE cells. Partial ATP depletion of MDCK cells by antimycin A was also shown to result in apoptosis with marked increase in activation of caspase-8 and inhibition of caspases provided marked protection against antimycin A-induced cell death [65]. Exposure of freshly isolated RTE to hypoxia resulted in caspase activation and cell membrane damage [66]. In a related study, activation of caspase-3 during hypoxia or ATP depletion was shown to be accompanied by bax translocation and cytochrome c release [67]. As in ischemia, cisplatin activates the caspase cascade as well. Cisplatin induces selective and differential activation of caspases including executioner caspase-3... 

A.F. Tramontane, R. Muniyappa, A.D. Black, M.C. Blendea, I. Cohen, L. Deng, J.R. Sowers, M.V. Cutaia and N. El-Sherif, Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway Biochem. Biophys. Res. Commun. 308, 990-994 (2003). 

Araya R, Uehara T, Nomura Y. 1998. Hypoxia induces apoptosis in human neuroblastoma. SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria. FEBS Lett 439 168-172. 

Banasiak KJ, Xia Y, Haddad GG. 2000. Mechanisms underlying hypoxia-induced neuronal apoptosis. Prog Neurobiol 62 215-249. 

Chae HJ, Kim SC, Han KS, Chae SW, An NH, et al. 2001. Hypoxia induces apoptosis by caspase activation accompanying cytochrome c release from mitochondria in MC3T3E1 osteoblasts, p38 MAPK is related in hypoxia-induced apoptosis. Immunopharm Immunotox23 133-152. 

Malhotra R, Brosius FC. 1999. Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes. J Biol Chem 274 12567-12575. 

Zaman K, Ryu H, HaU D, 0 Donovan K, Lin Kl, Miller MR Marquis JC, Baraban JM, Semenza GL, Ratan RR (1999) Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-l/CREB and increased expression of glycolytic enzymes, p21(wafl/cipl), and erythropoietin. J Neurosci 19 9821-9830... 

Hypobaric hypoxia-induced memory impairment has been attributed to several factors including increased oxidative stress, depleted mitochondrial bioenergetics, altered neurotransmission, and apoptosis. Hota et al. [24] expressed that administration of bacosides could be a useful therapeutic strategy in ameliorating hypobaric hypoxia-induced cognitive dysfunctions and other related neurological disorders. 

Suzuki H, Tomida A, Tsuruo T. Dephosphorylated hypoxia-inducible factor lot as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 2001 20 5779-5788. Goldberg M, Zhang HL, Steinberg SE Hypoxia alters the subcellular distribution of protein kinase C isoforms in neonatal rat ventricular myocytes. J Clin Invest 1997 99 55-61. 

Banasiak KJ, Cronin T, Haddad GG. bcl-2 Prolongs neuronal survival during hypoxia-induced apoptosis. Mol Brain Res 1999 72 214—225. 

Banasiak KJ, Haddad GG. Hypoxia-induced apoptosis effect of hypoxic severity and role of p53 in neuronal cell death. Brain Res 1998 797 295-304. 

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