Aprindine hydrochloride

Molnar, I., Wagner-Jauregg, T., Jahn, U. and Mixich, G. U.S. Patent 3,349,088 October 24, 1967 assigned to Siegfried AG, Switzerland 

Chemical Name N-[3-(Diethylamino)propyi] -N-phenyl-2-indanamine hydrochloride Common Name — 

N-Phenyi-2-aminoindane a-Chloropropyl Diethyl Amine Sodium Hydroxide 

6 g (0.5 mol) N-phenyl-2-aminoindane and 2.5 liters benzene are introduced into a reaction vessel of 5 liters, under an atmosphere of nitrogen. 37 g (0.95 moO sodium amide are added and the mixture is stirred during 3 hours at room temperature. 

7 g (0.8 mol) of 7-chloropropyl diethylamine are then quickly added. After agitation during 1 hour at room temperature, the reaction mixture is refluxed and stirred under nitrogen during 21 hours. The mixture is then allowed to cool and poured onto ice. The obtained equeous phase is extracted by means of 500 cm of benzene. The benzene extract is washed two times with 200 cm of water and the benzene is then evaporated. 

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A. D. Kosoy and G. Cooke, Characterizations of products derived from aprindine hydrochloride photolysis, J. Pharm. Sci., 67 122 (1978). 

Infra-red Spectrum. Principal peaks at wavenumbers 745, 1510, 1602,1187,1258,1035 (aprindine hydrochloride, KBr disk). 

Dose. 50 to 100 mg of aprindine hydrochloride daily initial doses of up to 200 mg daily may be given. 

Aprindine Hydrochloride 135-138 Cyclopentolate Hydrochloride 143-150 Oestradiol Valerate... 

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