Aorta polysaccharide

Histochemical methods have been used to follow changes in the acid mucopolysaccharides of human aortic tissue. Bertelsen and Jensen (1960) examined aortas from subjects up to 90 years old including some fetuses. The aortic tissue was found to contain both hyaluronic acid and sulfated mucopolysaccharides. The aortas of fetus and newborn contained 4iyalu-ronic acid as the major component. In aging the amount of sulfated polysaccharides increases up to about 50 years, especially in the media and intima, and after this time it is nearly constant. After 20 years of age, a periodic acid-Schiff (PAS) positive material is deposited in increasing amounts in the media and later in the intima. It was thought likely that the acid mucopolysaccharides are elaborated by the fibroblasts and the... 

A polysaccharide, isolated at first from pig skin in impure state , and thought to be identical to the chondroitin sulfate of cartilage, was found later to be chemically different, and was called chondroitin sulfate B . Further work established its presence in tendon, heart valves and aorta . The identity of this substance with a well characterized product possessing anticoagulant properties named /J-heparin , which had been isolated from the residual liquors of the preparation of heparin from beef lungs, was established. Since this polysaccharide is biologically and chemically different from the chondroitin sulfates, and from heparin, the name dermatan sulfate will be used in the present chapter. ... 

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