Antivirals sexually transmitted diseases

Sexually transmitted diseases (STDs) dendrimers as antiviral drugs against, 26 799... 

Spermicide-antiviral the polymer appears to be an effective delivery system for the spermicidal/antiviral agent nonoxynol-9. By its ability to adhere to vaginal tissue while retaining nonoxynol-9 in its gel structure, it is an excellent extended effect spermicide. As an antiviral, nonoxynol-9 can only kill free HIV and is not noticeably active when the virus is within a lymphocyte. In contrast, the bioadhesive gel containing nonoxynol-9 attaches to lymphocytes and maintains sufficient contact time to allow the nonoxynol-9 surfactant to disrupt the cell wall, thus eliminating the lymphocyte and killing the vims within. This suggests that the polymer may be useful in the prophylaxis of AIDS and the treatment of other sexually transmitted diseases. 

Araucaria angustifolia (Bert.) O. Kuntze (leaves) Bilobetin (3) II-7-O-methyl-robustaflavone (66) eupressuflavone (86). A Brazilian medicinal plant used for the treatment of various diseases, including dry skin, herpes disease, wounds, and sexually transmitted diseases. Bilobetin is an aetive leishmanicidal eompound. Antiviral activity antiherpes activity (Flerpes Simplex Virus type 1, HSV-1). Weniger et al., 2006[86] Freitas et al.,2009[79]. 

The antiviral properties of anionic polymers have recently received a lot of attention as agents to protect against infection with sexually transmitted diseases. Due to the cationic nature of most viruses, several anionic polymers are known to bind viruses. As early as the 1960s, researchers had studied the anti-viral properties of a variety of synthetic polymers [118]. However, not all anionic polymers inactivate viruses. Several classes of anionic polymers have been studied for their ability to inactivate the HIV virus. These polymers include poly(styrene-4-sulfonate), 2-naphthalenesulfonate-formaldehyde polymer, and acrylic acid-based polymers. Certain chemically modified natural polymers (i.e., semisynthetic) such as dextrin/dextran sulfates, cellulose sulfate, carrageenan sulfate, and cellulose acetate phthalate have also been investigated for this purpose. Of a number of such anionic polymers that have shown in-vitro and in vivo anti-HIV activity, a couple of polymeric drug candidates have proceeded to early stage human clinical trials for the evaluation of safety/tolerability [119]. While most of these have shown the desired tolerability and safety, further clinical trials are necessary to discern the therapeutic benefit and see if anionic polymers will be applicable as anti-HIV therapies. 

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