Antiherpes activity

In particular, acyclovir 1 has become important because of its potent antiherpes activity. Interest in this compound was further enhanced by the finding that, in HS V infected cells, its mechanism of action is due to its specific phosphorylation by the viral-encoded (but not cellular) thymidine kinase to acyclo GMP followed by further phosphorylation by cellular GMP and GDP kinases to the triphosphate, acyclo GTP, which is a selective and potent inhibitor of the HSV DNA polymerase.DHPA (3) and DHPG (2) "" also show significant antiviral activity. These findings have stimulated a widespread interest in. and led to the synthesis of. a large number of purine (and pyrimidine) acyclo nucleosides. " "... 

The antiherpes activity of four kinds of canthin-6-one alkaloids was assayed biologically together with 10 /3-carboline derivatives. Among these compounds, 8 and 28 had activity on a level with that of acyclovir, the control. It was noticed, however, that the therapeutic ratio was small 106). 

Araucaria angustifolia (Bert.) O. Kuntze (leaves) Bilobetin (3) II-7-O-methyl-robustaflavone (66) eupressuflavone (86). A Brazilian medicinal plant used for the treatment of various diseases, including dry skin, herpes disease, wounds, and sexually transmitted diseases. Bilobetin is an aetive leishmanicidal eompound. Antiviral activity antiherpes activity (Flerpes Simplex Virus type 1, HSV-1). Weniger et al., 2006[86] Freitas et al.,2009[79]. 

These two compounds may possess some clinical advantage over ara-A due to their low systemic toxicity. The antiviral effects of phosphonoformic acid (PFA, foscarnet sodium), which is presently in Phase III clinical trials in Europe, 3 have been discussed in a recent review.91 The synthesis and structural requirements for antiherpes activity of a series of PFA esters have also been reported.92... 

C11H14FN5O2 267.262 Powerful antiviral agent. Displays potent antiherpes activity in vitro and in vivo. Mp 109-113°. [a]g +Sl (H2O). 

Oien NL, Brideau RJ, Hopkins TA, Wieber JL, Knechtel ML, Shelly JA, Anstadt RA, Wells PA, Poorman RA, Huang A, Vaillancourt VA, Clayton TL, Tucker JA, Wathen MW (2002) Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors. Antimicrob Agents Chemother 46(3) 724 730... 

Schwarz B, Cech D, Reefschlaeger J (1984) A new method of the introduction of CEj- and C2F5-groups into pyrimidine derivatives and their antiherpes activity. J Prakt Chem 326 985-993... 

ANTIHERPES ACTIVITY OF BV-araU IN EXPERIMENTAL ANIMALS Effects on Mouse Model Infections with HSV-1... 

G. Stening, B. Gotthammar, A. Larsson, S. Alenius, N. G. Johansson, and B. Oeberg. Antiherpes activity... 

E. De Clercq. Biochemical aspects of the selective antiherpes activity of nucleoside analogues. Biochem. 

J. Reefschlaeger, G. Herrmann, D. Baerwolff, B. Schwarz, D. Cech, and P. Langen. Antiherpes activity... 

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