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Antitumor therapeutic agent

Carbocyclic analogues of nucleosides have attracted much attention as potential antiviral and antitumor therapeutic agents. Carbovir 72 is one of the most famous derivatives of this series, but its closely related analogue 1592U89 73 also holds remarkable promise for the treatment of AIDS and is currently in phase II clinical trials. [Pg.72]

The extract of earthworm can not only kill the cancer cells directly in vitro [78,79], but also inhibit the occurrence and development of cancer in vivo [23,80], EFE dissolves the fibrin around cancer cells when it is applied mutually with antitumor drugs. It helps antitumor drug to arrive at cancer, enhancing the drug s effect on the cells. It possibly becomes as a candidate to research the accessory antitumor therapeutic agent [18]. [Pg.840]

Neilsen PE (1999) Peptide nucleic acids as therapeutic agents. Curr Opin Struct Biol 9 353-357 Nelson EM, Tewey KM, Liu LF (1984) Mechanism of antitumor drug action poisoning of mammalian DNA topoisomerase II on DNA by 4 -(9-acridinylamino)-methanesulfon-m-anisidide. Proc Natl Acad Sci U S A 81(5) 1361-1365... [Pg.186]

Controlled-release technology based on the external temperature-activated release can find application in diverse industrial fields. In the pharmaceutical area, for example, the deviation of the body temperature from the normal temperature (37°C) in the physiological presence of the pathogens or pyrogens can be utilized as a useful stimulus that induces the release of the therapeutic agents from a thermosensitive controlled-release system. Physically controlled temperature using a heat source such as the microwaves from outside the body can also be used for temperature-activated antitumor drug release combined with the local hyperthermic treatment of cancer. [Pg.1777]

The studies mentioned above indicate that bromelain has a certain cytotoxic potential. It remains an open question whether the observed antineoplastic effects of bromelain preparations reside in the proteolytic enzyme or in some or more other components of the mixture. Before the work of Maurer et al. [104] and of Batkin et al. [105], the antitumor activity of bromelain was explained primarily by its fibrinolytic and platelet aggregation inhibitory activity, which is believed to interfere with the fibrin and coagulation features of tumor cells [2], More recently, Desser and Rehberger [107] demonstrated that bromelain stimulates the production of alpha tumor necrosis factor in human peripheral blood mononuclear cell cultures in a time-dependent manner. Immunomodulation, especially the release of cytokines, is believed to be responsible for the possible therapeutic potential of bromelain. However, further experimental evidence is necessary, first, to prove the antineoplastic action of the proteolytic enzyme, and second, to demonstrate that bromelain in vivo is a valuable therapeutic agent in humans. [Pg.146]

Befcxe the evolution of effective transfection methods and an understanding of molecular biological techniques, DNA and RNA were ad- ministered as potential therapeutic agents. For example, DNA from several sources displayed antitumor activity and the activity was reported to vary as a function of size, base i composition, and secondary structure (1-3). However, the molecular mechanisms by which DNA might induce antitumor effects were never defined and numerous other studies failed to demonstrate antitumor activities with DNA (4). [Pg.117]

There are many cancer therapeutic agents, which inhibit the metaphase progression. So, the in vivo antitumor activity of pironetin in... [Pg.28]

Development of 89 as an antitumor agent has been limited by its poor water solubility. However, reports of enhanced antitumor activity associated with the more water-soluble compounds such as aphidicolin-17-glycinate HC1 salt (135) and 16-fluoroaphidicolin (136) have revived interest in aphidicolin (89) and its analogs as potential therapeutic agents [52]. The potent activity of aphidicolin (89) is presumed to arise through its activity as a specific reversible inhibitor of DNA polymerase-a [51]. [Pg.235]


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See also in sourсe #XX -- [ Pg.30 , Pg.840 ]

See also in sourсe #XX -- [ Pg.840 ]




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Antitumoral agents

Therapeutic agent

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