Antiphlogistic

OC-Bisabolol. a-Bisabolol (99) occurs in camomile flowers and has been shown to be the main antiphlogistic and spasmolytic component of the European medicinal plant. The use of bisabolol is recommended mainly for its pharmacodynamic properties in cosmetic preparations for skin protection. 

Heteropentalenes, heterocycles with antiphlogistic properties 98CLY390. 

In the context of the synthesis of polymer-bound antiphlogistic drugs, a polymeric carboxylic acid was converted into the polyimidazolide, to which pharmaceutical agents were attached in the form of their amino esters [1571... 

Octahydroindoloquinolizidine. Racemic octahydroindoloquinolizidine (1) improves muscle-tone-caused hypothermia and inhibits spontaneous motor activity (327). It has been shown that 1 and its 11-methoxy derivative are useful as antiphlogistics (328). 

Wagner, H., and H. Flachsbarth. A new antiphlogistic principle from Sabal serrulata. 1. Planta Med 1981 41 244-251. 

SRI 29 Breu, W., M. Hagenlocher, K. Redl, G. Tittel, F. Stadler, and H. Wagner. Antiphlogistic activity of an extract from Sabal serrulata fruits prepared by supercritical carbon dioxide/in vitro inhibition of the cyclooxygenase and 5-lipoxygenase metabolism. Arzneim-forsch 1992 42(4) 547-551. 

More than 100 pharmaceutically active compounds of various prescription classes have been detected in water, livestock-derived manure, sewage, sediments, potable water, biosohds, and soil. The compounds detected belong to a wide range of classes of PPCPs, including antibiotics, antiphlogistics, antiepileptics, beta blockers, hpid regulators, vasodilators, and sympathomimetics. Most of the evidence for the presence of these compounds in the environment has been accumulated in aquatic systems. Occurrence in different matrices is also discussed. 

Chemical synthesis of racemates and subsequent resolution via crystallization of diastereomeric salts is employed in the preparation of rf-biotin and tocopherol (vitamins), dexchlorpheniramine (antihistaminic), levomepromazine (neuroleptic), levorphanol (analgesic), and naproxen (antiphlogistic), to note some examples4, threo-2-Amino-1 -(4-nitro-phenyl)-l,3-propanediol, an intermediate in the production of chloramphenicol, is resolved by crystallization with entrainment or via crystallization of the salt with camphorsulfonic acid4. Enzymatic resolutions are increasingly employed, normally via deacetylation of racemic acetates. This method has recently been used in the synthesis of carbacyclin derivatives5. 

The name antiphlogistic identifies the conceptual inversion of the new chemistry, while at the same time it implies some sort of connection with the view it replaced. Let us examine the parallels of the two systems. Can it be that the new chemistry was in some essential way just the old chemistry turned upside-down or inside-out The answer is, yes, and many scholars have noted that the chemistry described in phlogistic terms can be easily converted into antiphlogistic ones by replacing every reference to phlogiston with negative oxygen. 

These can be transformed into the antiphlogistic form by substituting negative oxygen for the phlogiston ... 

But recognizing today that the phlogistic view is not true, we tend to ignore its utility in its own time. We should recognize that Lavoisier s antiphlogistic doctrine replaced its predecessor not only because it was truer ... 

While Lavoisier was perfecting a new chemistry in the 1780s, he felt obliged to offer an account of the affinities of various substances with oxygen whose properties and behavior dominated his antiphlogistic doctrine. Early in the paper he speaks of the shortcomings of the traditional tables of affin-... 

Alstonia scholaris (L.) R. Br. Deng Tai Ye (Dita bark) (leaf) Picrinine, picralinal, echitamine, echitamidine.33 An expectorant, antiphlogistic. 

Canarium album Raeusch. C. sinense Rumph. Gan Lan (Chinese olive) (seed) Beta-carotene, thiamine, riboflavin, niacin, ascorbic acid.50 Antiphlogistic, astringent in pharngitis. 

Carpesium abrotanoides L. C. athunbergianum Sieb. et Zucc. He Shi or Tian Min Qing (Starwort) (whole plant, fruit) Essential oils, inlin.49 Ascariasis, enterobiasis, taeniasis, antiphlogistic in pharyngitis, tracheitis, laryngitis. 

Dracocephalum integrifolium L. Quao Ye Ging Lan (aerial plant) Essential oil, flavone glucoside.33 Antitussive, antiasthmatic, antiphlogistic, antibacterial. 

Eriocaulon sieboldianum Stend. E. buegerianum Koern. Ke Jing Cao (whole plant)50 No information is available in the literature. Antiphlogistic, diuretic, febrifuge, ophthalmic. 

Forsythia suspensa (Thunb.) Vahl. Lian Qiao (Forsythia) (leaf, fruit, root) Phillyrin, rutin, taraxasteryl palmitate and acetate, bigelovin, dihydrobigelovin.50-260 Febrifuge, for cancer, carbuncle, chickenpox, antiphlogistic, diuretic, emmenagogue, antiemetic, laxative, antipyretic. 

Fortunella crassifolia Swingle F. japonica (Thunb.) Swin. F. margarita (Lour.) Swin. Jin Gan Yuan Jin Gan Jin Ju (Kumquat) (whole plant) Glucosides, galactose, essential oil, pentosane, vitamin C.60 Antiphlogistic, antivinous, carminative, deodorizing, stimulant. 

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